Forscher Emily C, Prairie Michael L, Cook Jesse D, Notermann Sydney L, Plante David T
University of Wisconsin-Madison School of Medicine and Public Health, Department of Psychiatry, Madison, WI.
Department of Psychology, University of Wisconsin-Madison, Madison, WI.
Sleep Vigil. 2019;3(1):49-56. doi: 10.1007/s41782-019-00062-8. Epub 2019 May 15.
Hypersomnolence is a common and debilitating symptom in mood disorders. However, objective differentiation of excessive daytime sleepiness (EDS) from non-EDS in depression has not yet been achieved. This study compared performance on the Compensatory Tracking Task (CTT) and concurrently-recorded high-density (hd)EEG theta power in 22 patients with major depressive disorder (MDD) and co-occurring EDS against 22 age- and sex-matched patients with MDD but no EDS, as well as 22 age- and sex-matched healthy controls. Though depressed hypersomnolent participants endorsed feeling sleepier than depressed non-hypersomnolent and healthy control participants prior to starting the CTT, no group differences in CTT performance were observed. Average hdEEG theta power was higher during periods of high error on the CTT compared to periods of low error, but did not differ between the groups. Though the CTT still holds promise as an objective neurobehavioral measure, these results do not indicate a capability to differentiate EDS from non-EDS in mood disorders.
过度嗜睡是情绪障碍中一种常见且使人衰弱的症状。然而，目前尚未实现对抑郁症中白天过度嗜睡（EDS）与非EDS进行客观区分。本研究比较了22例伴有EDS的重度抑郁症（MDD）患者与22例年龄和性别匹配但无EDS的MDD患者以及22例年龄和性别匹配的健康对照者在代偿追踪任务（CTT）中的表现以及同时记录的高密度（hd）脑电图θ波功率。尽管在开始CTT之前，伴有过度嗜睡的抑郁参与者表示比不伴有过度嗜睡的抑郁参与者和健康对照参与者感觉更困倦，但未观察到CTT表现存在组间差异。与低错误期相比，CTT高错误期的平均hd脑电图θ波功率更高，但组间无差异。尽管CTT作为一种客观的神经行为测量方法仍有前景，但这些结果并未表明其有能力区分情绪障碍中的EDS与非EDS。
