Osawa J, Naito S, Aihara M, Kitamura K, Ikezawa Z, Nakajima H
Department of Dermatology, Yokohama City University School of Medicine, Japan.
J Dermatol. 1990 Apr;17(4):235-9. doi: 10.1111/j.1346-8138.1990.tb01631.x.
Skin test reactions were evaluated in 242 patients who appeared to develop delayed type drug eruptions from the clinical course. The patch testing was positive in 62 (31.5%) of 197 patients tested and the intradermal testing in 105 (89.7%) of 117 patients. The positive ratios of intradermal testing were higher in maculopapular (MP), erythema multiforme (EM), and erythrodermic (ED) types than in eczematous (Ecz) type drug eruptions, while those of patch testing were comparatively high in ED, Ecz type, and anticonvulsant-induced drug eruptions. It is considered that the combination of patch testing and intradermal testing is useful for determination of causative drugs in delayed type drug eruptions.
对242例从临床病程来看似乎发生迟发型药物疹的患者进行了皮肤试验反应评估。在197例接受检测的患者中，62例（31.5%）斑贴试验呈阳性，在117例患者中，105例（89.7%）皮内试验呈阳性。皮内试验的阳性率在斑丘疹（MP）型、多形红斑（EM）型和红皮病型（ED）药疹中高于湿疹型（Ecz）药疹，而斑贴试验的阳性率在ED型、Ecz型和抗惊厥药引起的药疹中相对较高。认为斑贴试验和皮内试验相结合有助于确定迟发型药物疹的致病药物。
