Rajasekaran Ekambaram, Vijayasarathy Marimuthu
Department of Bioinformatics, School of Biotechnology and Health Sciences, Karunya University, Coimbatore - 641114 Tamil Nadu, India.
Bioinformation. 2011 Feb 15;5(10):455-7. doi: 10.6026/97320630005455.
There are lots of works gone into proteins to understand the nature of proteins. Hydrophobic interaction is the dominant force that drives the proteins to carry out the biochemical reactions in all living system. Carbon is the only element that contributes towards this hydrophobic interaction. Studies find that globular proteins prefer to have 31.45% of carbon for its stability. Taking this as standard, a carbon analysis program has been developed to study the carbon distribution profile of protein sequences. This carbon analysis program has been made available online. This can be accessed at www.rajasekaran.net.in/tools/carbana.html. This new program is hoped to help in identification and development of active sites, study of protein stability, evolutionary understating of proteins, gene identification, ligand binding site identification, and to solve the long-standing problem of protein-protein and protein-DNA interactions.
为了了解蛋白质的本质，人们对蛋白质进行了大量研究。疏水相互作用是驱动蛋白质在所有生命系统中进行生化反应的主要力量。碳是促成这种疏水相互作用的唯一元素。研究发现，球状蛋白质为保持稳定性，碳含量倾向于为31.45%。以此为标准，已开发出一个碳分析程序来研究蛋白质序列的碳分布概况。这个碳分析程序已在线提供。可通过www.rajasekaran.net.in/tools/carbana.html访问。希望这个新程序有助于活性位点的识别与开发、蛋白质稳定性研究、蛋白质的进化理解、基因识别、配体结合位点识别，以及解决长期存在的蛋白质 - 蛋白质和蛋白质 - DNA相互作用问题。
