Ekambaram Rajasekaran, Kannaiyan Akila, Marimuthu Vijayasarathy, Swaminathan Vinobha Chinnaiah, Renganathan Senthil, Perumal Ananda Gopu
Department of Bioinformatics, School of Biotechnology and Health Sciences, Karunya University, Karunya Nagar, Coimbatore -641114, Tamil Nadu, India.
Department of Bioinformatics, Bishop Heber College, Trichy-620017, Tamil Nadu, India.
Bioinformation. 2014 Mar 19;10(3):138-43. doi: 10.6026/97320630010138. eCollection 2014.
Spatial arrangement of carbon in protein structure is analyzed here. Particularly, the carbon fractions around individual atoms are compared. It is hoped that it follows the principle of 31.45% carbon around individual atoms. The results reveal that globular protein's atoms follow this principle. A comparative study on monomer versus dimer reveal that carbon is better distributed in dimeric form than in its monomeric form. Similar study on solid versus liquid structures reveals that the liquid (NMR) structure has better carbon distribution over the corresponding solid (X-Ray) structure. The carbon fraction distributions in fiber and toxin protein are compared. Fiber proteins follow the principle of carbon fraction distribution. At the same time it has another broad spectrum of carbon distribution than in globular proteins. The toxin protein follows an abnormal carbon fraction distribution. The carbon fraction distribution plays an important role in deciding the structure and shape of proteins. It is hoped to help in understanding the protein folding and function.
本文分析了蛋白质结构中碳的空间排列。特别地，比较了单个原子周围的碳含量。希望单个原子周围的碳含量遵循31.45%的原则。结果表明，球状蛋白质的原子遵循这一原则。对单体与二聚体的比较研究表明，碳以二聚体形式比以单体形式分布得更好。对固态与液态结构的类似研究表明，液态（核磁共振）结构比相应的固态（X射线）结构具有更好的碳分布。比较了纤维蛋白和毒素蛋白中的碳含量分布。纤维蛋白遵循碳含量分布原则。同时，它具有比球状蛋白更广泛的碳分布范围。毒素蛋白的碳含量分布异常。碳含量分布在决定蛋白质的结构和形状方面起着重要作用。希望有助于理解蛋白质的折叠和功能。
