Rajasekaran Ekambaram
Department of Bioinformatics, School of Biotechnology and Health Sciences, Karunya University, Karunya Nagar, Coimbatore 641114.
Bioinformation. 2012;8(11):508-12. doi: 10.6026/97320630008508. Epub 2012 Jun 16.
Carbon distribution is responsible for stability and structure of proteins. Arrangement of carbon along the protein sequence is depends on how the amino acids are organized and is guided by mRNAs. An atomic level revision is important for understanding these codes. This will ultimately help in identification of disorders and suggest mutations. For this purpose a carbon distribution analysis program has been developed. This program captures the hydrophobic / hydrophilic / disordered regions in a protein. The program gives accurate results. The calculations are precise and sensitive to single amino acid resolution. This program is to help in mutational studies leading to protein stabilisation.
碳分布决定了蛋白质的稳定性和结构。碳沿着蛋白质序列的排列取决于氨基酸的组织方式，并受信使核糖核酸（mRNA）的引导。原子水平的修正对于理解这些编码很重要。这最终将有助于识别疾病并提出突变情况。为此，已经开发了一个碳分布分析程序。该程序能够捕捉蛋白质中的疏水/亲水/无序区域。该程序给出的结果准确。计算精确且对单个氨基酸分辨率敏感。这个程序有助于进行导致蛋白质稳定的突变研究。
