暴露于十溴联苯醚（BDE-209）中对蚯蚓（赤子爱胜蚓）的羟基自由基生成和氧化应激的影响。
Hydroxyl radical generation and oxidative stress in earthworms (Eisenia fetida) exposed to decabromodiphenyl ether (BDE-209).
机构信息
State Key Laboratory of Pollution Control and Resource Reuse, Center for Hydrosciences Research, School of the Environment, Nanjing University, Nanjing, 210093, People's Republuic of China.
出版信息
Ecotoxicology. 2011 Jul;20(5):993-9. doi: 10.1007/s10646-011-0645-x. Epub 2011 Mar 22.
Antioxidant responses induced by decabromodiphenyl ether (BDE-209) in the earthworms (Eisenia fetida) were studied after 7 days of exposure. Electron paramagnetic resonance (EPR) spectra indicated that hydroxyl radicals (•OH) in earthworms were significantly induced by 0.01-10 mg/kg of BDE-209. Malondialdehyde (MDA) and protein carbonyl (PCO) were stimulated at 0.5-10 mg/kg and 1-10 mg/kg, respectively. The reduced glutathione (GSH) was inhibited at 1-10 mg/kg while oxidized glutathione (GSSG) accumulated at 0.5-10 mg/kg. The GSH/GSSG ratio decreased at 0.5-10 mg/kg, and superoxide dismutase (SOD) and glutathione-S-transferase (GST) activities were induced at 0.1-1 and 0.5 mg/kg, respectively and both decreased at 10 mg/kg. Catalase (CAT) activities increased at 1-10 mg/kg. The results showed that severe oxidative stress occurred in E. fetida, and may play an important role in inducing the toxicity of BDE-209 on earthworms.
研究了十溴联苯醚（BDE-209）暴露 7 天后对蚯蚓（赤子爱胜蚓）的抗氧化反应。电子顺磁共振（EPR）谱表明，0.01-10mg/kg 的 BDE-209 可显著诱导蚯蚓中的羟基自由基（•OH）。丙二醛（MDA）和蛋白质羰基（PCO）分别在 0.5-10mg/kg 和 1-10mg/kg 时受到刺激。还原型谷胱甘肽（GSH）在 1-10mg/kg 时受到抑制，氧化型谷胱甘肽（GSSG）在 0.5-10mg/kg 时积累。GSH/GSSG 比值在 0.5-10mg/kg 时降低，超氧化物歧化酶（SOD）和谷胱甘肽-S-转移酶（GST）活性分别在 0.1-1mg/kg 和 0.5mg/kg 时被诱导，而在 10mg/kg 时则降低。过氧化氢酶（CAT）活性在 1-10mg/kg 时增加。结果表明，E. fetida 发生严重的氧化应激，这可能在诱导 BDE-209 对蚯蚓的毒性中发挥重要作用。
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