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[皮肤病的疾病管理指南:以手部湿疹管理指南为例的实施、潜力与局限]

[Disease management guidelines in dermatology: implementation, potentials and limitations exemplified by the guidelines for the management of hand eczema].

作者信息

Emmert B, Hallier E, Schön M P, Emmert S

机构信息

AfB Betriebsarztzentrum Göttingen, Göttingen, Deutschland.

出版信息

Hautarzt. 2011 Apr;62(4):308-14. doi: 10.1007/s00105-011-2128-7.

DOI:10.1007/s00105-011-2128-7
PMID:21424892
Abstract

In Germany, the "Arbeitsgemeinschaft der Wissenschaftlichen Medizinischen Fachgesellschaften" (AWMF; consortium of scientific medical societies) constitutes the umbrella organisation to conceive, evaluate, and release guidelines. There are 3 stages of development (S1-S3) according to the evidence level and the process of consensus finding. Currently, 59 dermatologic guidelines have been published under the auspices of the Deutsche Dermatologische Gesellschaft (German Dermatological Society). The guideline for the management of hand dermatitis (AWMF-Register-No: 013/053) is an instructive recent example. This guideline clearly demonstrates the benefits of guidelines, i.e. standardized definition of heterogeneous diseases and disease severity as well as standardized therapy algorithms. This is especially important in diseases difficult-to-treat like chronic hand dermatitis. The effective implementation of guidelines with early incorporation of new therapies, for example alitretinoin in the therapy of hand dermatitis, can considerably improve the quality of life of patients.

摘要

在德国,“医学专业科学协会联盟”(AWMF;医学科学协会联合体)是负责制定、评估和发布指南的总括性组织。根据证据水平和达成共识的过程,有三个发展阶段(S1 - S3)。目前,在德国皮肤病学会的支持下已发布了59项皮肤病学指南。手部皮炎管理指南(AWMF登记号:013/053)就是一个近期具有指导意义的例子。该指南清楚地展示了指南的益处,即对异质性疾病和疾病严重程度进行标准化定义以及标准化治疗算法。这在像慢性手部皮炎这种难以治疗的疾病中尤为重要。早期纳入新疗法(例如在手部皮炎治疗中使用阿利维A酸)来有效实施指南,可显著提高患者的生活质量。

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本文引用的文献

1
Cost-effectiveness of oral alitretinoin in patients with severe chronic hand eczema--a long-term analysis from a Swiss perspective.从瑞士视角看口服阿利维A酸治疗重度慢性手部湿疹的成本效益——一项长期分析
BMC Dermatol. 2010 Jun 25;10:4. doi: 10.1186/1471-5945-10-4.
2
[Classification, trigger factors and course of chronic hand eczema].[慢性手部湿疹的分类、触发因素及病程]
MMW Fortschr Med. 2009 May 7;151(19):31-4.
3
Guideline on the management of hand eczema ICD-10 Code: L20. L23. L24. L25. L30.手部湿疹管理指南 ICD - 10 编码:L20、L23、L24、L25、L30。
J Dtsch Dermatol Ges. 2009 May;7 Suppl 3:S1-16. doi: 10.1111/j.1610-0387.2009.07061.x.
4
Alitretinoin as a potential advance in the management of severe chronic hand eczema.
Arch Dermatol. 2009 Mar;145(3):314-5. doi: 10.1001/archdermatol.2008.608.
5
Efficacy and safety of oral alitretinoin (9-cis retinoic acid) in patients with severe chronic hand eczema refractory to topical corticosteroids: results of a randomized, double-blind, placebo-controlled, multicentre trial.口服阿利维A酸(9-顺式维甲酸)治疗对局部用皮质类固醇难治的重度慢性手部湿疹患者的疗效与安全性:一项随机、双盲、安慰剂对照、多中心试验的结果
Br J Dermatol. 2008 Apr;158(4):808-17. doi: 10.1111/j.1365-2133.2008.08487.x. Epub 2008 Feb 21.
6
Hand eczema is common and multifactorial.手部湿疹很常见且病因多为综合性。
J Invest Dermatol. 2007 Jul;127(7):1568-70. doi: 10.1038/sj.jid.5700781.