Davidson Terry L, Martin Ashley A, Clark Kiely, Swithers Susan E
Department of Psychological Sciences, Purdue University, West Lafayette, IN 47907, USA.
Q J Exp Psychol (Hove). 2011 Jul;64(7):1430-41. doi: 10.1080/17470218.2011.552729.
Recent results from both human epidemiological and experimental studies with animals suggest that intake of noncaloric sweeteners may promote, rather than protect against, weight gain and other disturbances of energy regulation. However, without a viable mechanism to explain how consumption of noncaloric sweeteners can increase energy intake and body weight, the persuasiveness of such results has been limited. Using a rat model, the present research showed that intake of noncaloric sweeteners reduces the effectiveness of learned associations between sweet tastes and postingestive caloric outcomes (Experiment 1) and that interfering with this association may impair the ability of rats to regulate their intake of sweet, but not nonsweet, high-fat and high-calorie food (Experiment 2). The results support the hypothesis that consuming noncaloric sweeteners may promote excessive intake and body weight gain by weakening a predictive relationship between sweet taste and the caloric consequences of eating.
近期人类流行病学研究和动物实验研究的结果表明，摄入无热量甜味剂可能会促进体重增加和其他能量调节紊乱，而不是起到预防作用。然而，由于缺乏一个可行的机制来解释无热量甜味剂的摄入如何增加能量摄入和体重，这些结果的说服力有限。本研究使用大鼠模型表明，摄入无热量甜味剂会降低甜味与摄食后热量结果之间习得关联的有效性（实验1），并且干扰这种关联可能会损害大鼠调节甜味（而非非甜味）高脂肪和高热量食物摄入量的能力（实验2）。这些结果支持了以下假设：食用无热量甜味剂可能会通过削弱甜味与进食热量后果之间的预测关系来促进过量摄入和体重增加。
