Department of Pharmacy, Zhujiang Hospital, Southern Medical University, Guangzhou 510282, China.
J Microencapsul. 2011;28(3):183-9. doi: 10.3109/02652048.2010.544419.
A rapid expansion from supercritical solution into aqueous solution (RESSAS) technology was presented for the micronization of Chinese medicinal material. Magnolia bark extract (MBE) obtained by supercritical carbon dioxide (scCO₂) extraction technology was chosen as the experimental material. RESSAS process produced 303.0 nm nanoparticles (size distribution, 243.6-320.5 nm), which was significantly smaller than the 55.3 µm particles (size distribution, 8.3-102.4 µm) prepared by conventional mechanical milling. The effect of process parameters, including extraction temperature (30 °C, 40 °C, 50 °C), extraction pressure (200, 250, 300 bar) and nozzle size (50, 100, 200 µm), on the size distribution of nanoparticles was investigated. The characteristics of nanoparticles and materials were also studied by scanning electron microscopy (SEM) and laser light scattering (LLS). This study demonstrates that RESSAS is applicable for preparing nanoparticles of MBE at low operating temperature; the process is simple without any residual solvent.
快速膨胀从超临界溶液到水溶液（RESSAS）技术被提出用于中药的微粉化。采用超临界二氧化碳（scCO₂）萃取技术获得的厚朴提取物（MBE）作为实验材料。RESSAS 工艺生产的 303.0nm 纳米颗粒（粒径分布，243.6-320.5nm）明显小于常规机械研磨制备的 55.3μm 颗粒（粒径分布，8.3-102.4μm）。考察了工艺参数对纳米颗粒粒径分布的影响，包括萃取温度（30°C、40°C、50°C）、萃取压力（200、250、300 巴）和喷嘴尺寸（50、100、200μm）。还通过扫描电子显微镜（SEM）和激光光散射（LLS）研究了纳米颗粒和材料的特性。本研究表明，RESSAS 适用于在低操作温度下制备 MBE 的纳米颗粒；该工艺简单，无任何残留溶剂。
