惊恐障碍患者中高亲和力血小板[3H]麦角酸二乙酰胺结合能力降低。

High-affinity platelet [3H]LSD binding is decreased in panic disorder.

作者信息

Norman T R, Judd F K, Staikos V, Burrows G D, McIntyre I M

机构信息

Department of Psychiatry, University of Melbourne, Austin Hospital, Heidelberg, Vic., Australia.

出版信息

J Affect Disord. 1990 Jun;19(2):119-23. doi: 10.1016/0165-0327(90)90016-2.

DOI:10.1016/0165-0327(90)90016-2

PMID:2142698

Abstract

Platelet [3H]LSD binding was measured in 15 patients with panic attacks and 15 controls. The mean (+/- SD) Bmax values of the patients (14.1 +/- 6.3 fmol/mg protein) and of the controls (18.5 +/- 4.7 fmol/mg protein) were significantly different (P less than 0.05, Mann-Whitney U-test). Mean (+/- SD) values of Kd for the patients (0.55 +/- 0.34 nM) and for the controls (0.51 +/- 0.12 nM) were not significantly different (P greater than 0.1, Mann-Whitney U-test). The results are discussed in terms of a serotonergic hypothesis of the aetiology of panic disorders.

摘要

对15名恐慌症发作患者和15名对照者进行了血小板[3H]麦角酰二乙胺结合检测。患者的平均（±标准差）最大结合容量（Bmax）值为（14.1±6.3飞摩尔/毫克蛋白质），对照者为（18.5±4.7飞摩尔/毫克蛋白质），二者有显著差异（P<0.05，曼-惠特尼U检验）。患者的解离常数（Kd）平均（±标准差）值为（0.55±0.34纳摩尔），对照者为（0.51±0.12纳摩尔），二者无显著差异（P>0.1，曼-惠特尼U检验）。根据恐慌症病因的血清素能假说对结果进行了讨论。