Norman T R, Judd F K, Burrows G D, McIntyre I M
Department of Psychiatry, University of Melbourne, Victoria, Australia.
Psychiatry Res. 1989 Oct;30(1):63-8. doi: 10.1016/0165-1781(89)90172-8.
Platelet serotonin uptake was measured in 29 patients with DSM-III panic disorder or agoraphobia with panic attacks and compared to values obtained in 23 controls. Both the affinity constant (Km) and the maximal rate of uptake (Vmax) were determined in a buffered medium using 14C-serotonin. Patients and controls did not differ significantly with respect to age or Km values. A statistically significant difference was observed for Vmax (mean +/- SD = 65 +/- 22 pmol/10(8) platelet/min in patients vs. 44 +/- 13 pmol/10(8) platelets/min in controls). This finding suggests an overactivity of peripheral serotonergic function in panic disorder, which may also imply a similar dysfunction centrally.
对29名患有DSM-III惊恐障碍或伴有惊恐发作的广场恐惧症患者的血小板5-羟色胺摄取进行了测量，并与23名对照者的值进行了比较。使用14C-5-羟色胺在缓冲介质中测定亲和常数（Km）和最大摄取率（Vmax）。患者和对照者在年龄或Km值方面无显著差异。观察到Vmax有统计学显著差异（患者平均±标准差=65±22 pmol/10(8)个血小板/分钟，对照者为44±13 pmol/10(8)个血小板/分钟）。这一发现表明惊恐障碍患者外周5-羟色胺能功能亢进，这也可能意味着中枢存在类似的功能障碍。
