惊恐障碍中的血小板5-羟色胺摄取

Platelet serotonin uptake in panic disorder.

作者信息

Norman T R, Judd F K, Gregory M, James R H, Kimber N M, McIntyre I M, Burrows G D

出版信息

J Affect Disord. 1986 Jul-Aug;11(1):69-72. doi: 10.1016/0165-0327(86)90062-5.

Abstract

Platelet serotonin uptake was measured in 45 patients (12 males, 33 females) with panic attacks and 21 controls (9 males, 12 females). Higher Vmax values were obtained in the patient group than in the controls (100.2 +/- 11.5 vs. 34.9 +/- 3.8 pmol/10(8) platelets/min; P less than 0.0005) while the affinity constant Km was not significantly different (2.28 +/- 0.3 vs. 1.71 +/- 0.18 microM). A value of Vmax in excess of 60 pmol/10(8) platelets/min was observed in 60% of patients and in only 5% of controls. The results point to a specific abnormality of platelet serotonin uptake in patients with panic attacks.

摘要

对45例惊恐发作患者（12例男性，33例女性）和21名对照者（9例男性，12例女性）进行了血小板5-羟色胺摄取量测定。患者组的Vmax值高于对照组（100.2±11.5对34.9±3.8 pmol/10⁸血小板/分钟；P<0.0005），而亲和常数Km无显著差异（2.28±0.3对1.71±0.18 microM）。60%的患者Vmax值超过60 pmol/10⁸血小板/分钟，而对照组仅为5%。结果表明惊恐发作患者血小板5-羟色胺摄取存在特异性异常。