Dell'Acqua S, De Cicco Nardone F, Benedetto M T, Iacobelli S, Rossiello F, Bongiorno M, Margariti P A
Department of Obstetrics & Gynecology, Università Cattolica S. Cuore, Rome, Italy.
Ann N Y Acad Sci. 1990;595:334-47. doi: 10.1111/j.1749-6632.1990.tb34307.x.
The hormone sensitivity of endometrial carcinoma is related to the presence of steroid hormone receptors. The determination of progesterone receptors has been proposed in order to predict clinical prognosis and to aid treatment selection. The integrity of the hormone receptor system and postreceptoral events in tumors is essential to endocrine therapy response. Nevertheless, although hormone receptors are present in a large number of endometrial carcinomas, only 30% of cases respond to hormone therapy. In some neoplasms the receptors can be present, but not functioning, or else neoplastic transformation could have induced alterations in processes after hormone-receptor interaction.
子宫内膜癌的激素敏感性与甾体激素受体的存在有关。为预测临床预后及辅助治疗选择，已提出检测孕激素受体。肿瘤中激素受体系统的完整性及受体后事件对于内分泌治疗反应至关重要。然而，尽管大量子宫内膜癌存在激素受体，但仅有30%的病例对激素治疗有反应。在某些肿瘤中，受体可能存在但无功能，或者肿瘤转化可能已引起激素受体相互作用后过程中的改变。
