Sangha G K, Kaur Kamalpreet, Khera K S, Singh Balwinder
Department of Zoology, Punjab Agricultural University, Ludhiana-141004, India.
Toxicol Int. 2011 Jan;18(1):5-8. doi: 10.4103/0971-6580.75844.
A study was undertaken to evaluate the effects of cypermethrin on reproduction of female albino rats. The experimental rats were fed cypermethrin at 50 mg/kg b. wt. continuously for a period of 2 and 4 weeks. Feed and water intake was also noted daily for control, vehicle treated and cypermethrin-treated rats. It was observed that there was no effect on feed and water intake in treated rats as compared to the control group. Chronic exposure to cypermethrin for 4 weeks resulted in loose fecal pellets and hyperirritability in the treated rats. Treatment related mortality also occurred at the 4(th) wk of treatment. Significant changes in body weight and various organ weights due to cypermethrin were observed along with disruption of estrous cycle in rats. The body weight gain in treated rats was lower at both 2 and 4 weeks as compared to the control rats. The weight of liver and spleen decreased, while that of kidneys increased as compared to the control rats. Thyroid and adrenal showed increase in weight at both 2 and 4 weeks of treatments.
开展了一项研究以评估氯氰菊酯对雌性白化大鼠繁殖的影响。将实验大鼠以50毫克/千克体重的剂量连续2周和4周喂食氯氰菊酯。每天还记录对照组、赋形剂处理组和氯氰菊酯处理组大鼠的采食量和饮水量。观察到与对照组相比,处理组大鼠的采食量和饮水量没有受到影响。氯氰菊酯慢性暴露4周导致处理组大鼠出现粪便松散和过度易激惹。在处理的第4周也发生了与处理相关的死亡。观察到氯氰菊酯导致大鼠体重和各种器官重量发生显著变化,同时发情周期紊乱。与对照大鼠相比,处理组大鼠在2周和4周时的体重增加均较低。与对照大鼠相比,肝脏和脾脏重量下降,而肾脏重量增加。在处理的2周和4周时,甲状腺和肾上腺重量均增加。