Ortiz Darlene Mae D, Park Juyoung, Lee Handule, Park Kwangsik
College of Pharmacy, Dongduk Women's University, Seoul 02748, Republic of Korea.
Toxics. 2024 Mar 15;12(3):218. doi: 10.3390/toxics12030218.
Pyrethroids, which are derived from natural insecticides found in chrysanthemum flowers, are widely utilized in various sectors, including agriculture, forestry, horticulture, and personal insect protection. Due to their widespread use, concerns have arisen regarding their potential estrogenic effects on female reproductive health. This review aims to address data gaps and inconsistencies in previous studies by defining molecular initiating events and key events within the adverse outcome pathway associated with pyrethroid-induced estrogenic effects. To achieve this, we propose utilizing Integrated Approaches to Testing and Assessment (IATA), which incorporate in vitro assays and in vivo assessments to comprehensively investigate the estrogenic effects of pyrethroids. An initial search was conducted in the PubMed database to identify relevant articles. Subsequently, the findings were classified according to the IATA strategy. This review provides an overview of the current understanding of pyrethroids and their estrogenic effects, identifies data gaps, and highlights the use of IATA in existing studies on the estrogenic effects of various pyrethroids. It emphasizes the urgent need for comprehensive research on the estrogenic effects of pyrethroids and highlights the importance of standardized testing methods like IATA to accurately assess their impact on human and environmental health. By promoting the use of Integrated Testing Strategies (ITSs) and addressing data gaps, researchers and regulators can enhance the accuracy of assessments, ensuring better protection of human and environmental health from the potential estrogenic effects of pyrethroid exposure.
拟除虫菊酯是从菊花中发现的天然杀虫剂衍生而来，广泛应用于农业、林业、园艺和个人防虫等各个领域。由于其广泛使用，人们对其对女性生殖健康的潜在雌激素效应产生了担忧。本综述旨在通过定义与拟除虫菊酯诱导的雌激素效应相关的不良结局途径中的分子起始事件和关键事件，来解决先前研究中的数据空白和不一致问题。为实现这一目标，我们建议采用综合测试与评估方法（IATA），该方法结合了体外试验和体内评估，以全面研究拟除虫菊酯的雌激素效应。首先在PubMed数据库中进行搜索以识别相关文章。随后，根据IATA策略对研究结果进行分类。本综述概述了目前对拟除虫菊酯及其雌激素效应的理解，识别了数据空白，并强调了IATA在现有各种拟除虫菊酯雌激素效应研究中的应用。它强调了对拟除虫菊酯雌激素效应进行全面研究的迫切需求，并突出了像IATA这样的标准化测试方法对于准确评估其对人类和环境健康影响的重要性。通过推广使用综合测试策略（ITSs）并解决数据空白，研究人员和监管机构可以提高评估的准确性，确保更好地保护人类和环境健康免受拟除虫菊酯暴露潜在雌激素效应的影响。
