Cochrane S M, Parent J M, Black W D, Allen D G, Lumsden J H
Department of Clinical Studies, Ontario Veterinary College, University of Guelph.
Can J Vet Res. 1990 Jun;54(3):309-12.
Phenobarbital was administered orally to seven healthy cats at a dose of 5 mg/kg once a day for 21 days. Serum phenobarbital concentrations were determined using a commercial immunoassay technique. A one-compartment model was used to describe the final elimination curve. The elimination half-life (t1/2 b) after the final day of treatment was 43.3 +/- 2.92 h. The large apparent volume of distribution of 695.0 +/- 43.9 mL/kg suggests that the drug was widely distributed within the body. The t1/2 b following multiple oral administration was significantly shorter than previously reported for a single oral dose of phenobarbital in the cat. Analysis of pharmacokinetic results after days 1 and 21 of treatment suggested that the elimination kinetics of phenobarbital did not change significantly with multiple oral administration. It appears that differences in elimination kinetics can exist between populations of cats. These differences emphasize the need for individual monitoring of cats receiving phenobarbital.
对7只健康猫口服苯巴比妥，剂量为5毫克/千克，每日一次，持续21天。使用商业免疫测定技术测定血清苯巴比妥浓度。采用一室模型描述最终消除曲线。治疗最后一天后的消除半衰期（t1/2 b）为43.3±2.92小时。695.0±43.9毫升/千克的较大表观分布容积表明该药物在体内广泛分布。多次口服给药后的t1/2 b明显短于先前报道的猫单次口服苯巴比妥的情况。治疗第1天和第21天后的药代动力学结果分析表明，多次口服给药后苯巴比妥的消除动力学没有显著变化。似乎不同猫群之间的消除动力学可能存在差异。这些差异强调了对接受苯巴比妥治疗的猫进行个体监测的必要性。
