Faculty of Veterinary Medicine, Hokkaido University Veterinary Teaching Hospital, Hokkaido University, Hokkaido, Japan.
Department of Veterinary Clinical Pathobiology, Veterinary Medical Center, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo, Japan.
Open Vet J. 2023 Jul;13(7):846-853. doi: 10.5455/OVJ.2023.v13.i7.6. Epub 2023 Jul 31.
Idiopathic epilepsy in cats is a more common disease than previously thought, but little information is available about the medical treatment of feline idiopathic epilepsy.
To assess the therapeutic efficacy and safety of antiseizure medication (ASM) for a minimum of 6 months, including zonisamide (ZNS), in feline idiopathic epilepsy at a referral hospital in Japan.
Twenty cats diagnosed with idiopathic epilepsy treated with ASMs were retrospectively included.
Nine cats that were finally treated with phenobarbital (PB) monotherapy reached the primary goal (the seizure frequency after the treatment intervention was less than one seizure every 3 months). Three cats were treated with ZNS monotherapy and two reached the primary goal. Eight cats finally received combination therapy. Two of the three cats receiving PB and ZNS therapy achieved the primary goal, but one was considered no responder. Five cats [PB + diazepam (DZP), ZNS + DZP, and ZNS + levetiracetam + DZP] decreased the seizure frequency and reached the primary goal in all but one cat reached the secondary goal. Adverse events were observed in eight patients, but these were curable. Two patients had vomiting after ZNS monotherapy, one had diarrhea, and another was an increase in sleeping hours.
PB was frequently used and seemed effective as both monotherapy and combination therapy. Some cats were treated with ASM protocols containing ZNS. ZNS may be available to treat idiopathic epilepsy in cats. However, ZNS administration may cause adverse events, such as gastrointestinal toxicity, in cats.
猫特发性癫痫比之前认为的更为常见，但关于猫特发性癫痫的医学治疗方法的信息却很少。
评估日本某转诊医院使用抗癫痫药物（ASM）治疗猫特发性癫痫至少 6 个月的疗效和安全性，包括佐米曲普坦（ZNS）。
回顾性纳入 20 例诊断为特发性癫痫并接受 ASM 治疗的猫。
最终接受苯巴比妥（PB）单药治疗的 9 例猫达到了主要目标（治疗干预后发作频率低于每 3 个月 1 次）。3 例猫接受 ZNS 单药治疗，其中 2 例达到主要目标。8 例猫最终接受联合治疗。接受 PB 和 ZNS 治疗的 3 例猫中有 2 例达到主要目标，但有 1 例被认为无反应。5 例猫[PB+地西泮（DZP）、ZNS+DZP、ZNS+左乙拉西坦+DZP]降低了发作频率并达到主要目标，除 1 例外，所有猫均达到次要目标。8 例猫出现不良反应，但均可以治愈。2 例猫在接受 ZNS 单药治疗后出现呕吐，1 例出现腹泻，另 1 例是睡眠时间增加。
PB 经常被使用，无论是单药治疗还是联合治疗都似乎有效。一些猫接受了含有 ZNS 的 ASM 方案治疗。ZNS 可能可用于治疗猫特发性癫痫。然而，ZNS 给药可能会导致猫出现胃肠道毒性等不良反应。
