Manyak M J, Nelson L M, Solomon D, DeGraff W, Stillman R J, Russo A
Radiation Oncology Branch, National Cancer Institute, Bethesda, Maryland.
Fertil Steril. 1990 Aug;54(2):356-9. doi: 10.1016/s0015-0282(16)53720-0.
A model for early stage endometriosis was prepared in rabbits by intraperitoneal injection of monodispersed viable endometrial cells. With this model, we have found that DHE fluorescence increases the sensitivity of detection of endometrial tissue. The potential experimental and clinical significance of ectopic endometrial detection by porphyrin fluorescence is enhanced by the recent report of endometrial transplant destruction by PDT. Although caution must be exercised for extrapolation from animal experiments to human conditions, these results encourage further evaluation of photosensitization for the study and potential treatment of disorders involving endometrial tissue.
通过腹腔注射单分散的活子宫内膜细胞，在兔子身上制备了早期子宫内膜异位症模型。利用该模型，我们发现脱氢表雄酮（DHE）荧光可提高子宫内膜组织检测的灵敏度。卟啉荧光检测异位子宫内膜的潜在实验和临床意义因近期关于光动力疗法（PDT）破坏子宫内膜移植的报告而得到增强。尽管从动物实验推断人类情况时必须谨慎，但这些结果鼓励进一步评估光致敏作用，以用于涉及子宫内膜组织的疾病的研究和潜在治疗。
