Nseyo U O, Mang T S, Potter W R
J Urol. 1986 Dec;136(6):1363-6. doi: 10.1016/s0022-5347(17)45339-0.
The techniques of in vivo tissue fluorescence photometry and chemical extractions of DHE, which have been recently developed in our laboratory, were employed to study DHE uptake and clearance in the primate bladders. Data show these techniques are readily applicable in studying porphyrin uptake and clearance in primate bladders. Quantitatively a correlation between fluorescence values and tissue extracted DHE values is found. Serum clearance and bladder clearance of DHE appeared phasic, but bladder clearance was slower than serum. The significance of these two methods lies in their applications in determination of drug dosimetry and optimum time for photoactivation in clinical photodynamic therapy.
我们实验室最近开发的体内组织荧光光度法和二氢卟吩化学提取技术，被用于研究灵长类动物膀胱中二氢卟吩的摄取和清除。数据表明，这些技术很容易应用于研究灵长类动物膀胱中卟啉的摄取和清除。在荧光值和组织提取的二氢卟吩值之间发现了定量相关性。二氢卟吩的血清清除率和膀胱清除率呈阶段性，但膀胱清除率比血清清除率慢。这两种方法的意义在于它们在临床光动力治疗中药物剂量测定和光激活最佳时间的确定中的应用。
