Pfefferle W, Anke H, Bross M, Steffan B, Vianden R, Steglich W
Department of Biotechnology, University of Kaiserslautern, FRG.
J Antibiot (Tokyo). 1990 Jun;43(6):648-54. doi: 10.7164/antibiotics.43.648.
Asperfuran is a novel antifungal dihydrobenzofuran derivative produced by a strain of Aspergillus oryzae. Asperfuran weakly inhibited chitin synthase from Coprinus cinereus. This inhibition could be abolished by the addition of egg lecithin. In the agar diffusion assay asperfuran induced morphological changes in Mucor miehei at very low concentrations (20 ng/disc) while growth was only partly inhibited. In HeLa S3 and L1210 cells it showed weak cytotoxicity, the IC50 was 25 micrograms/ml.
曲霉呋喃是由米曲霉菌株产生的一种新型抗真菌二氢苯并呋喃衍生物。曲霉呋喃对灰盖鬼伞的几丁质合成酶有微弱抑制作用。添加卵磷脂可消除这种抑制作用。在琼脂扩散试验中，曲霉呋喃在极低浓度（20纳克/圆片）时就能诱导米黑根毛霉发生形态变化，而生长仅受到部分抑制。在HeLa S3细胞和L1210细胞中，它表现出微弱的细胞毒性，半数抑制浓度为25微克/毫升。
