Seidler Yvonne, Rimbach Gerald, Lüersen Kai, Vinderola Gabriel, Ipharraguerre Ignacio R
Institute of Human Nutrition and Food Science, Division of Food Science, Faculty of Agricultural and Nutritional Sciences, University of Kiel, Kiel, Germany.
Instituto de Lactología Industrial (CONICET-UNL), Faculty of Chemical Engineering, National University of Litoral, Santa Fe, Argentina.
Front Microbiol. 2024 Oct 23;15:1452725. doi: 10.3389/fmicb.2024.1452725. eCollection 2024.
The filamentous fungus has a long tradition in East Asian food processing. It is therefore not surprising that in recent years fermentation products of have attracted attention in the emerging field of postbiotics. This review aims to provide a comprehensive summary of the potential postbiotic effects of fermentation products from , by discussing possible mechanisms of action against the background of the molecular composition determined so far. In particular, cell wall constituents, enzymes, extracellular polymeric substances, and various metabolites found in fermentation preparations are described in detail. With reference to the generally assumed key targets of postbiotics, their putative beneficial bioactivities in modulating the microbiota, improving epithelial barrier function, influencing immune responses, metabolic reactions and signaling through the nervous system are assessed. Drawing on existing literature and case studies, we highlight as a promising source of postbiotics, particularly in the context of animal health and nutrition. Challenges and opportunities in quality control are also addressed, with a focus on the necessity for standardized methods to fully harness the potential of fungal-based postbiotics. Overall, this article sheds light on the emerging field of -derived postbiotics and emphasizes the need for further research to fully realize their therapeutic potential.
丝状真菌在东亚食品加工领域有着悠久的传统。因此,近年来其发酵产物在新兴的后生元领域引起关注也就不足为奇了。本综述旨在通过在迄今确定的分子组成背景下讨论可能的作用机制,全面总结其发酵产物潜在的后生元效应。特别详细描述了在其发酵制剂中发现的细胞壁成分、酶、细胞外聚合物和各种代谢产物。参照后生元普遍假定的关键靶点,评估了它们在调节微生物群、改善上皮屏障功能、影响免疫反应、代谢反应以及通过神经系统进行信号传导方面的推定有益生物活性。借鉴现有文献和案例研究,我们强调其作为后生元的一个有前景的来源,特别是在动物健康和营养方面。还讨论了质量控制方面的挑战和机遇,重点是需要标准化方法以充分发挥基于真菌的后生元的潜力。总体而言,本文阐明了其衍生后生元这一新兴领域,并强调需要进一步研究以充分实现其治疗潜力。