Division of Neurology, Department of Internal Medicine, Faculty of Medicine, Prince of Songkla University, Hat Yai, Songkhla, 90110, Thailand.
Qual Life Res. 2011 Nov;20(9):1519-23. doi: 10.1007/s11136-011-9890-y. Epub 2011 Mar 24.
This study was undertaken to assess the impact of hemifacial spasm (HFS) and blepharospasm (BS) on quality of life (QOL) during long-term treatment with botulinum toxin injections.
Fifty-three patients with HFS and 32 patients with BS as well as two healthy age- and sex-matched control groups were included in the study. All participants independently completed the disease-specific questionnaire for QOL, the HFS-30, and the Thai Depression Inventory, and also provided a peak improvement score assessment.
The disease severity in both patient groups revealed mild functional impairment. The scores of HFS-30 in HFS patients (four of 8 subscales) and BS patients (3 of 8 subscales) were significantly higher than the control groups. In both HFS and BS, depression scores were positively correlated with the HFS-30 scores, while peak improvement and educational level were inversely correlated with the HFS-30 scores. Patients with BS were more affected in Mobility and Activities of Daily Living than HFS patients.
Both HFS and BS affect QOL both physically and mentally despite clinical improvement with botulinum toxin. Depression and peak improvement after injection were associated with the level of QOL.
本研究旨在评估肉毒毒素注射治疗对面肌痉挛（HFS）和眼睑痉挛（BS）患者长期生活质量（QOL）的影响。
本研究纳入了 53 例 HFS 患者和 32 例 BS 患者，以及两组年龄和性别匹配的健康对照组。所有参与者均独立完成了疾病特异性 QOL 问卷、HFS-30 和泰国抑郁量表，并提供了峰值改善评分评估。
两组患者的疾病严重程度均显示出轻度的功能障碍。HFS 患者（8 个亚量表中的 4 个）和 BS 患者（8 个亚量表中的 3 个）的 HFS-30 评分显著高于对照组。在 HFS 和 BS 中，抑郁评分与 HFS-30 评分呈正相关，而峰值改善和教育水平与 HFS-30 评分呈负相关。BS 患者在移动能力和日常生活活动方面比 HFS 患者受影响更大。
尽管肉毒毒素注射可改善临床症状，但 HFS 和 BS 仍会对患者的身体和心理健康产生影响。注射后的抑郁和峰值改善与 QOL 水平相关。
