健康人群中腰围与血清一氧化氮浓度的关系。
Association of abdominal circumference with serum nitric oxide concentration in healthy population.
机构信息
Department of Medical Technology, Nagoya University School of Health Sciences, 1-20 Daikominami I-chome, Higashi-ku, 461-8673, Nagoya, Japan,
出版信息
Environ Health Prev Med. 2006 Nov;11(6):321-5. doi: 10.1007/BF02898023.
OBJECTIVES
We determined the relationship between abdominal circumference and the concentration of nitric oxide (NO), an endothelial cell product known to play an important role in the regulation of vascular tone and thrombocyte activations.
METHODS
Subjects were 177 men and 339 women aged 40 or over who were free from a history of diabetes or malignancy. Analysis of covariance was applied to examine the gender-specific and smoking-status-specific associations of abdominal fat volume measured as waist circumference, waist-hip ratio, and waist-to-stature ratio, with serum NO level represented by the concentration of NO metabolites (NOx; nitrate plus nitrite).
RESULTS
Although men showed no statistical association between abdominal fat accumulation and NOx concentration, abdominal adiposity seemed to inversely affect the serum NOx concentration of never- and current-smoking women.
CONCLUSION
Our results suggest that a reduction in NO bioactivity occurs with abdominal fat accumulation in women. The underlying biological mechanism might involve adipocytokines secreted from visceral fat, but is yet to be elucidated.
目的
我们旨在确定腹围与一氧化氮（NO）浓度之间的关系。NO 是一种内皮细胞产物，已知其在调节血管张力和血小板激活方面发挥着重要作用。
方法
研究对象为 177 名男性和 339 名年龄在 40 岁及以上、无糖尿病或恶性肿瘤病史的人群。我们采用协方差分析的方法，检验了腰围、腰臀比和腰高比等腹部脂肪量指标与血清一氧化氮代谢产物（NOx，硝酸盐加亚硝酸盐）浓度代表的血清 NO 水平之间的性别特异性和吸烟状态特异性关联。
结果
尽管男性的腹部脂肪堆积与 NOx 浓度之间没有统计学关联，但从不吸烟和当前吸烟的女性中，腹部肥胖似乎会对血清 NOx 浓度产生相反的影响。
结论
我们的研究结果表明，女性腹部脂肪堆积会导致一氧化氮生物活性降低。潜在的生物学机制可能涉及内脏脂肪分泌的脂肪细胞因子，但这仍有待阐明。
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