Department of Public Health and Hygiene, Faculty of Medicine, Oita Medical University, Oita.
Environ Health Prev Med. 1996 Oct;1(3):136-43. doi: 10.1007/BF02931205.
To allow adoption of serum pepsinogen as a screening indicator of gastric cancer, serum pepsinogen I & II levels, the ratios of PG I / PG II and the serum gastrin levels in a general population were studied using 850 samples selected at random from a rural area in Japan. The collected data were analyzed statistically to determine the distribution characteristics by various categories of sex and age. The following results were obtained:1. The distributions of PG I and PG II, the ratios of PG I/PG II and serum gastrin values largely deviated from the normal distribution. Therefore, the use of non-parametrical methods was recommended for analysis of these data.2. Although no significant difference between all selected men and all selected women was observed in any of the three parameters of PG I and PG II levels and the ratios of PG I / PG II, a significant difference between men and women was observed for PG I levels in under-fifty age groups. On the other hand, the median serum gastrin value (92.0 pg/ml) in all selected men was significantly lower than that (101.0 pg/ml) in all selected women. A statistically significant difference between men and women was observed in serum gastrin levels both in the under-forty age group and in the sixty and over age group.3. No significant difference was observed in the pattern of changes in PG I levels with increasing age in either men or women. While PG II levels in men varied irregularly with advancing age, PG II levels in women showed obvious increases with advancing age. The ratios of PG I / PG II showed a tendency to decrease with advancing age in both men and women. Conversely, serum gastrin levels increased with advancing age in both men and women.
为了将血清胃蛋白酶原作为胃癌筛查指标加以采用，我们对随机抽取的日本某农村地区的 850 名居民的血清胃蛋白酶原 I & II 水平、PG I / PG II 比值和血清胃泌素水平进行了研究。我们对所采集的数据进行了统计学分析，以确定不同性别和年龄组的分布特征。结果如下：1. PG I 和 PG II 的分布、PG I / PG II 比值和血清胃泌素值都严重偏离正态分布。因此，建议使用非参数方法对这些数据进行分析。2. 在 PG I 和 PG II 水平以及 PG I / PG II 比值的三个参数中，所有男性和所有女性之间没有观察到显著差异，但在 50 岁以下年龄组中男性的 PG I 水平存在显著差异。另一方面，所有男性的血清胃泌素中位数（92.0 pg/ml）显著低于所有女性的血清胃泌素中位数（101.0 pg/ml）。在 40 岁以下年龄组和 60 岁以上年龄组中，男性和女性的血清胃泌素水平都存在统计学差异。3. 无论是男性还是女性，PG I 水平随年龄增长的变化模式都没有显著差异。男性的 PG II 水平随年龄的增长而不规则波动，而女性的 PG II 水平随年龄的增长而明显增加。PG I / PG II 比值呈随年龄增长而降低的趋势，无论男女。相反，男性和女性的血清胃泌素水平都随年龄的增长而增加。
