坦桑尼亚联合共和国和多米尼加共和国的幽门螺杆菌感染和慢性萎缩性胃炎的血清流行率。
Seroprevalences ofHelicobacter pylori infection and chronic atrophic gastritis in the united Republic of Tanzania and the Dominican Republic.
机构信息
Division of Preventive Medicine, Department of Human Environmental and Social Medicine, Faculty of Medicine, Oita University, 879-5593, Hasama, Oita, Japan,
出版信息
Environ Health Prev Med. 2004 Jul;9(4):170-5. doi: 10.1007/BF02898097.
OBJECTIVE
The aim of this survey was to compare the seroprevalences ofHelicobacter Pylori (H. pylori) and chronic atrophic gastritis (CAG) in Tanzania and the Dominican Republic, both of which are tropical countries, and thereafter compare the prevalences in Tanzania and the Dominican Republic with prevalences from our previous studies done in Japan (1991) and China (1996/97).
METHODS
Community-based study in which 573 inhabitants of Tanzania and 1,215 inhabitants of the Dominican Republic answered detailed questionnaires on upper digestive tract diseases, and then underwent screening for gastric cancer by serum pepsinogen and testing for antibody toH. pylori.
RESULTS
After adjusting to the 'Age-Standardized Rate' (ASR) using the world population in 1995, the seroprevalences ofH. pylori infection in male and female subjects for Tanzania (m=85.3% & f=88.2%) were very high compared to those for the Dominican Republic (m=63.5% & f=62.4%) and Japan (m=62.0% & f=46.8%), and similar to those of China (m=78.0% & f=77.3%). Also, the agestandardized prevalences of CAG in males and females for Tanzania (m-0.237& f=0.458). were higher than those of the Dominican Republic (m=0.168 & f=0.211) and China (m=0.111 & f=0.107) and compared well with those of Japan (m=0.266 & f=0.352).
CONCLUSIONS
Although Tanzania and the Dominican Republic are both developing countries, Tanzania had a very high age-standardized prevalence ofH. pylori and CAG compared to that of the Dominican Republic, which showed a trend similar to that of Japan.
目的
本研究旨在比较坦桑尼亚和多米尼加共和国（均为热带国家）人群中幽门螺杆菌（H. pylori）感染和慢性萎缩性胃炎（CAG）的血清流行率，并与我们在日本（1991 年）和中国（1996/97 年）的既往研究结果进行比较。
方法
采用基于社区的研究方法，对 573 名坦桑尼亚居民和 1215 名多米尼加共和国居民进行了上消化道疾病详细问卷调查，然后通过血清胃蛋白酶原和 H. pylori 抗体检测进行胃癌筛查。
结果
经 1995 年世界人口年龄标准化率（ASR）校正后，坦桑尼亚男性和女性人群的 H. pylori 感染血清流行率（男性为 85.3%，女性为 88.2%）明显高于多米尼加共和国（男性为 63.5%，女性为 62.4%）和日本（男性为 62.0%，女性为 46.8%），与中国（男性为 78.0%，女性为 77.3%）相似。此外，坦桑尼亚男性和女性人群的 CAG 年龄标准化患病率（男性为 0.237，女性为 0.458）高于多米尼加共和国（男性为 0.168，女性为 0.211）和中国（男性为 0.111，女性为 0.107），与日本（男性为 0.266，女性为 0.352）的结果相当。
结论
尽管坦桑尼亚和多米尼加共和国都是发展中国家，但与多米尼加共和国相比，坦桑尼亚的 H. pylori 和 CAG 年龄标准化流行率非常高，与日本的趋势相似。
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