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肝细胞癌治疗和诊断策略:从高通量和分析方法中得到的经验教训。

Strategies for hepatocellular carcinoma therapy and diagnostics: lessons learned from high throughput and profiling approaches.

机构信息

Institute of Pathology, University Hospital, Heidelberg, Germany.

出版信息

Hepatology. 2011 Jun;53(6):2112-21. doi: 10.1002/hep.24313.

DOI:10.1002/hep.24313
PMID:21433041
Abstract

Over the last decade, numerous small and high-dimensional profiling analyses have been performed in human hepatocellular carcinoma (HCC), which address different levels of regulation and modulation. Because comprehensive analyses are lacking, the following review summarizes some of the general results and compares them with insights from other tumor entities. Particular attention is given to the impact of these results on future diagnostic and therapeutic approaches.

摘要

在过去的十年中,已经在人类肝细胞癌 (HCC) 中进行了许多小型和高维的分析,这些分析涉及不同层次的调控。由于缺乏全面的分析,因此本文综述了一些一般结果,并将其与来自其他肿瘤实体的见解进行了比较。特别关注这些结果对未来诊断和治疗方法的影响。

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Strategies for hepatocellular carcinoma therapy and diagnostics: lessons learned from high throughput and profiling approaches.肝细胞癌治疗和诊断策略:从高通量和分析方法中得到的经验教训。
Hepatology. 2011 Jun;53(6):2112-21. doi: 10.1002/hep.24313.
2
Molecular biological diagnosis and gene therapy of hepatocellular carcinoma: the present status.肝细胞癌的分子生物学诊断与基因治疗:现状
Zhonghua Yi Xue Za Zhi. 2003 May 10;83(9):724-5.
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High-dimensional biology to comprehend hepatocellular carcinoma.运用高维生物学理解肝细胞癌。
Expert Rev Proteomics. 2008 Feb;5(1):45-60. doi: 10.1586/14789450.5.1.45.
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[The application of gene chip in the diagnosis and treatment of hepatocellular carcinoma].[基因芯片在肝细胞癌诊断与治疗中的应用]
Zhonghua Gan Zang Bing Za Zhi. 2004 May;12(5):317-8.
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Proteomics for the early detection and treatment of hepatocellular carcinoma.用于肝细胞癌早期检测与治疗的蛋白质组学
Oncogene. 2006 Jun 26;25(27):3810-7. doi: 10.1038/sj.onc.1209551.
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Genetic profiling of human hepatocellular carcinoma.人类肝细胞癌的基因谱分析
Semin Liver Dis. 2005;25(2):125-32. doi: 10.1055/s-2005-871192.
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Molecular mechanisms of hepatocellular carcinoma.肝细胞癌的分子机制
Hepatology. 2008 Dec;48(6):2047-63. doi: 10.1002/hep.22580.
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Hcc-2, a novel mammalian ER thioredoxin that is differentially expressed in hepatocellular carcinoma.Hcc-2,一种在肝细胞癌中差异表达的新型哺乳动物内质网硫氧还蛋白。
FEBS Lett. 2006 Apr 17;580(9):2216-26. doi: 10.1016/j.febslet.2006.03.029. Epub 2006 Mar 20.
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[microRNA: new diagnostic and therapeutic tools in liver disease?].[微小RNA:肝脏疾病的新型诊断和治疗工具?]
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MicroRNA-500 as a potential diagnostic marker for hepatocellular carcinoma.微小 RNA-500 作为肝细胞癌的潜在诊断标志物。
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利用下一代测序技术鉴定出的与高肿瘤突变负担相关的驱动基因对肝细胞癌免疫治疗的影响
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Early Changes in Circulating FGF19 and Ang-2 Levels as Possible Predictive Biomarkers of Clinical Response to Lenvatinib Therapy in Hepatocellular Carcinoma.循环中FGF19和Ang-2水平的早期变化作为肝细胞癌患者对乐伐替尼治疗临床反应的潜在预测生物标志物
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Radiopharmaceuticals and Fluorescein Sodium Mediated Triple-Modality Molecular Imaging Allows Precise Image-Guided Tumor Surgery.放射性药物与荧光素钠介导的三模态分子成像实现精确的影像引导肿瘤手术。
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Cancer Metabolism as a Mechanism of Treatment Resistance and Potential Therapeutic Target in Hepatocellular Carcinoma.癌症代谢作为肝细胞癌治疗耐药机制及潜在治疗靶点
Yonsei Med J. 2018 Dec;59(10):1143-1149. doi: 10.3349/ymj.2018.59.10.1143.
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Implementation of systems theory in liver cancer research.系统理论在肝癌研究中的应用
Hepat Oncol. 2015 Jan;2(1):9-11. doi: 10.2217/hep.14.29. Epub 2015 Jan 12.
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The biological and clinical challenge of liver cancer heterogeneity.肝癌异质性的生物学和临床挑战。
Hepat Oncol. 2014 Oct;1(4):349-353. doi: 10.2217/hep.14.18. Epub 2014 Dec 11.
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In Vivo Phosphoproteome Analysis Reveals Kinome Reprogramming in Hepatocellular Carcinoma.在体磷酸化蛋白质组分析揭示肝癌中的激酶组重编程。
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HBx-mediated decrease of AIM2 contributes to hepatocellular carcinoma metastasis.HBx 介导的 AIM2 减少促进肝癌转移。
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