Binauld Sandra, Damiron Denis, Connal Luke A, Hawker Craig J, Drockenmuller Eric
Center for Advanced Macromolecular Design, School of Chemical Engineering, The University of New South Wales, UNSW Sydney, NSW 2052, Australia.
Macromol Rapid Commun. 2011 Jan 17;32(2):147-68. doi: 10.1002/marc.201000548. Epub 2010 Dec 3.
The synthesis of perfectly defined (macro)molecules has been a constant challenge for polymer and organic chemists. This paper highlights the main applications of the iterative divergent/convergent approach for the synthesis of discrete mass oligomers and polymers. We will discuss the orthogonal deprotection and coupling strategies involved in this powerful strategy where chain length doubles at each iteration and which has been applied to the synthesis of conjugated rigid rods as well as amorphous and crystalline oligomers and polymers. The synthesis of perfectly defined oligomers in respect to emerging highly efficient and orthogonal chemistries will also be highlighted.
对于聚合物和有机化学家而言，合成结构完全确定的（宏观）分子一直是一项持续的挑战。本文重点介绍了迭代发散/收敛方法在离散质量低聚物和聚合物合成中的主要应用。我们将讨论这一强大策略中涉及的正交脱保护和偶联策略，该策略在每次迭代时链长翻倍，已应用于共轭刚性棒以及无定形和结晶低聚物及聚合物的合成。还将重点介绍基于新兴的高效正交化学合成结构完全确定的低聚物。
