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[高血压患者膜钙 -ATP 酶功能及膜脂质非酶促过氧化作用]

[The function of membrane Ca-ATPases and nonenzymatic peroxidation of membrane lipids in patients with hypertension].

作者信息

Siurin A A, Kulagin Iu I, Anikin E I, Prokhoda A F, Kabeliuzhenko S B, Shcherbina L I

出版信息

Vopr Med Khim. 1990 May-Jun;36(3):69-71.

PMID:2143337
Abstract

Alterations in activity of membrane-bound Ca2(+)-ATPases were shown to depend on the rate of lipid peroxidation in cell membranes of patients with hypertension during the period of crisis. On the basis from these results antioxidants and Ca2(+)-antagonistic drugs could be used for treatment of hypertensive crisis. Monitoring of the disease is possible by means of estimation of the membrane-bound Ca2(+)-ATPases activity.

摘要

在高血压患者危机期间,已表明膜结合钙ATP酶活性的改变取决于细胞膜中脂质过氧化的速率。基于这些结果,抗氧化剂和钙拮抗药物可用于治疗高血压危象。通过评估膜结合钙ATP酶活性可以对疾病进行监测。

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