Lapkin V A, Losev N A
Farmakol Toksikol. 1978 Nov-Dec;41(6):670-3.
The action of pheprazet, a derivative of amphethamine, and of the pheprazet alkylated analogues on the excitability of the neuron populations in the dorsal and ventral parts of the hippocampus was studied in non-anesthetized rabbits with electrodes and chemotrodes indwelt in the hippocampus and other brain structures. Most active drugs are shown to be pheprazet and (formula: see text). The former affects the beta- and the latter the alpha-adrenoreceptors of the hippocampus. Pheprazet pre-eminently increases while the drug (see formula: see text) reduces the excitability of the neuron populations in the dorsal and ventral parts of the hippocampus. The opposite effects of these drugs are considered by authors from the standpoint of interaction between different mediator systems.
在未麻醉的家兔身上，通过将电极和化学探针植入海马体及其他脑结构，研究了苯丙胺衍生物苯哌乙胺及其烷基化类似物对海马体背侧和腹侧神经元群兴奋性的作用。结果表明，最具活性的药物是苯哌乙胺和（分子式：见原文）。前者作用于海马体的β-肾上腺素能受体，后者作用于α-肾上腺素能受体。苯哌乙胺显著提高了海马体背侧和腹侧神经元群的兴奋性，而药物（见分子式：见原文）则降低了其兴奋性。作者从不同介质系统之间相互作用的角度考虑了这些药物的相反作用。
