从细胞培养到人体对阿片类药物疗效、耐受性、成瘾性和依赖性的分析。
Analysis of opioid efficacy, tolerance, addiction and dependence from cell culture to human.
机构信息
Department of Psychology, Washington State University Vancouver, Vancouver, WA, USA.
出版信息
Br J Pharmacol. 2011 Oct;164(4):1322-34. doi: 10.1111/j.1476-5381.2011.01335.x.
Abstract
Opioid agonists are the most effective treatment for pain, but their use is limited by side effects, tolerance and fears of addiction and dependence. A major goal of opioid research is to develop agonists that have high analgesic efficacy and a low profile for side effects, tolerance, addiction and dependence. Unfortunately, there is a serious lack of experimental data comparing the degree to which different opioids produce these effects in humans. In contrast, a wide range of experimental techniques from heterologous expression systems to behaviour assessment in whole animals have been developed to study these problems. The objective of this review is to describe and evaluate these techniques as they are used to study opioid efficacy, tolerance, addiction and dependence.
摘要
阿片类激动剂是治疗疼痛最有效的药物，但由于其副作用、耐受性以及对成瘾和依赖的担忧，其应用受到限制。阿片类药物研究的主要目标是开发具有高镇痛效果和低副作用、耐受性、成瘾和依赖风险的激动剂。不幸的是，目前非常缺乏比较不同阿片类药物在人体中产生这些作用程度的实验数据。相比之下，已经开发出了从异源表达系统到整体动物行为评估的广泛的实验技术，用于研究这些问题。本综述的目的是描述和评估这些技术，因为它们被用于研究阿片类药物的疗效、耐受性、成瘾和依赖性。
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