Findlay J K, Sai X, Shukovski L
Prince Henry's Institute of Medical Research, Monash Medical Centre, Melbourne, Vic., Australia.
Reprod Fertil Dev. 1990;2(3):205-18.
Evidence for intragonadal roles of the inhibin-related peptides, activin, inhibin, alpha N peptide of inhibin (alpha N) and follicle-stimulating hormone suppressing protein (FSP) or follistatin, is reviewed. It is proposed that activin, FSP and alpha N act as intragonadal regulators to influence folliculogenesis, ovulation and luteinization, and that inhibin primarily influences folliculogenesis by its peripheral effects on the secretion of FSH and LH by the pituitary gland, with few, if any, effects directly within the ovarian follicle. We propose that activin promotes follicular differentiation and delays the onset of premature luteinization, whereas FSP promotes atresia of non-dominant follicles and luteinization of dominant follicles, and is therefore antagonistic to activin. We hypothesize that alpha N, a post-translational processing product of the alpha subunit of inhibin, acts locally in the follicle to facilitate ovulation.
本文综述了抑制素相关肽、激活素、抑制素、抑制素αN肽（αN）以及卵泡刺激素抑制蛋白（FSP）或卵泡抑素在性腺内作用的证据。有人提出，激活素、FSP和αN作为性腺内调节因子，影响卵泡发生、排卵和黄体化，而抑制素主要通过其对垂体分泌促卵泡生成素（FSH）和促黄体生成素（LH）的外周作用来影响卵泡发生，在卵巢卵泡内即使有直接作用也很少。我们提出，激活素促进卵泡分化并延迟过早黄体化的开始，而FSP促进非优势卵泡的闭锁和优势卵泡的黄体化，因此与激活素拮抗。我们推测，αN是抑制素α亚基的翻译后加工产物，在卵泡局部发挥作用以促进排卵。
