Cancer Diagnosis Program, Division of Cancer Treatment and Diagnosis, National Cancer Institute, 6130 Executive Blvd, Executive Plaza North, Rockville, MD 20852, USA.
J Natl Cancer Inst. 2011 Apr 20;103(8):628-35. doi: 10.1093/jnci/djr094. Epub 2011 Mar 24.
Each year in the United States, nearly 70 000 individuals between the ages of 15 and 40 years are diagnosed with cancer. Although overall cancer survival rates among pediatric and older adult patients have increased in recent decades, there has been little improvement in survival of adolescent and young adult (AYA) cancer patients since 1975 when collected data became adequate to evaluate this issue. In 2006, the AYA Oncology Progress Review Group made recommendations for addressing the needs of this population that were later implemented by the LIVESTRONG Young Adult Alliance. One of their overriding questions was whether the cancers seen in AYA patients were biologically different than the same cancers in adult and/or pediatric patients. On June 9-10, 2009, the National Cancer Institute (NCI) and the Lance Armstrong Foundation (LAF) convened a workshop in Bethesda, MD, entitled "Unique Characteristics of AYA Cancers: Focus on Acute Lymphocytic Leukemia (ALL), Breast Cancer and Colon Cancer" that aimed to examine the current state of basic and translational research on these cancers and to discuss the next steps to improve their prognosis and treatment.
每年在美国，有近 70000 名年龄在 15 岁至 40 岁之间的个体被诊断患有癌症。尽管儿科和老年患者的整体癌症生存率在最近几十年有所提高，但自 1975 年开始收集数据足以评估这个问题以来，青少年和年轻成人（AYA）癌症患者的生存率几乎没有改善。2006 年，AYA 肿瘤学进展审查小组提出了满足这一人群需求的建议，后来由 LIVESTRONG 青年成人联盟实施。他们的一个首要问题是，AYA 患者中出现的癌症是否与成人和/或儿科患者中相同的癌症在生物学上有所不同。2009 年 6 月 9 日至 10 日，美国国家癌症研究所（NCI）和兰斯·阿姆斯特朗基金会（LAF）在马里兰州贝塞斯达举行了一次研讨会，题为“AYA 癌症的独特特征：关注急性淋巴细胞白血病（ALL）、乳腺癌和结肠癌”，旨在检查这些癌症的基础和转化研究的现状，并讨论改善其预后和治疗的下一步措施。
