Lewis Samara L, Stewart Kenneth E, Garwe Tabitha, Sarwar Zoona, Morris Katherine T
Department of Surgery, The University of Oklahoma Health Sciences Center, 800 Stanton L. Blvd, Oklahoma City, OK 73190, USA.
Cancers (Basel). 2022 Aug 6;14(15):3817. doi: 10.3390/cancers14153817.
Introduction: Colon cancer among young patients has increased in incidence and mortality over the past decade. Our objective was to determine if age-related differences exist for total positive nodes (TPN), total lymph node harvest (TLH), and lymph node ratio (LNR). Material and Methods: A retrospective review of stage III surgically resected colorectal cancer patient data in the National Cancer Database (2004−2016) was performed, reviewing TPN, TLH, and LNR (TPN/TLH). Results: Unadjusted analyses suggested significantly higher levels of TLH and TPN (p < 0.0001) in younger patients, while LNR did not differ by age group. On adjusted analysis, TLH remained higher in younger patients (<35 years 1.56 (CI 95 1.54, 1.59)). The age-related effect was less pronounced for LNR (<35 years 1.16 (CI 95 1.13, 1.2)). Conclusion: Younger patients have increased TLH, even after adjusting for known confounders, while age does not have a strong independent impact on LNR.
引言：在过去十年中，年轻患者的结肠癌发病率和死亡率均有所上升。我们的目的是确定在总阳性淋巴结（TPN）、总淋巴结切除数（TLH）和淋巴结比率（LNR）方面是否存在与年龄相关的差异。材料与方法：对国家癌症数据库（2004 - 2016年）中III期手术切除的结直肠癌患者数据进行回顾性分析，观察TPN、TLH和LNR（TPN/TLH）。结果：未经调整的分析表明，年轻患者的TLH和TPN水平显著更高（p < 0.0001），而LNR在各年龄组之间无差异。经调整分析后，年轻患者（<35岁）的TLH仍然更高（1.56（95%置信区间1.54，1.59））。年龄对LNR的影响不那么明显（<35岁为1.16（95%置信区间1.13，1.2））。结论：即使在对已知混杂因素进行调整后，年轻患者的TLH仍然增加，而年龄对LNR没有强烈的独立影响。
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