Denk B, Filser J G, Deml E, Kessler W, Shen J, Oesterle D
GSF-Institut für Toxikologie, Neuherberg, Federal Republic of Germany.
Arch Toxicol. 1990;64(4):329-31. doi: 10.1007/BF01972994.
Male and female Sprague-Dawley rats, 4-6 days old were exposed for 3 weeks (6 h/day, 5 days/week) to 2-nitropropane vapours of 0, 25, 40, 50, 80 and 125 ppm. One week later polychlorinated biphenyls (Clophen A50, 10 mg/kg body weight) were administered for promotion twice a week for 8 weeks. Thirteen weeks after starting the experiments the logarithms of the numbers of preneoplastic liver foci deficient in adenosine-5'-triphosphatase were found to be linearly related to the exposure concentrations of 2-nitropropane. Male rats exhibited an approximately four times lower foci incidence than females.
