Williams G M, Mori H, McQueen C A
American Health Foundation, Valhalla, NY 10595.
Mutat Res. 1989 Nov;221(3):263-86. doi: 10.1016/0165-1110(89)90039-0.
312 chemicals/mixtures were tested for genotoxicity in the rat hepatocyte/DNA-repair test. A variety of structure-activity relationships was evident. Of the 309 pure chemicals, 142 were positive. Of these, 43 were judged by IARC to have sufficient or limited evidence of carcinogenicity and none of the remainder was a proven noncarcinogen. Among the 167 negative chemicals, 44 were carcinogens. Some of these are known to be genotoxic in other systems, but based on several lines of evidence, many are considered to be epigenetic carcinogens that lack the ability to react with DNA and rather lead to neoplasia by nongenotoxic mechanisms.
在大鼠肝细胞/DNA修复试验中对312种化学物质/混合物进行了遗传毒性测试。各种构效关系很明显。在309种纯化学物质中，142种呈阳性。其中，43种被国际癌症研究机构（IARC）判定有充分或有限的致癌证据，其余的都不是已证实的非致癌物。在167种阴性化学物质中，44种是致癌物。其中一些在其他系统中已知具有遗传毒性，但基于多方面证据，许多被认为是表观遗传致癌物，它们缺乏与DNA反应的能力，而是通过非遗传毒性机制导致肿瘤形成。
