环棱肽A与人血清白蛋白的生物分子相互作用研究
Biomolecular interaction study of Cyclolinopeptide A with human serum albumin.
作者信息
Rempel Ben, Gui Bo, Maley Jason, Reaney Martin, Sammynaiken Ramaswami
机构信息
Department of Biochemistry, University of Saskatchewan, Saskatoon, SK, Canada S7N 5E5.
出版信息
J Biomed Biotechnol. 2010;2010:737289. doi: 10.1155/2010/737289. Epub 2011 Mar 10.
The kinetics, energetics, and structure of Cyclolinopeptide A binding with Human Serum Albumin were investigated with surface plasmon resonance and circular dichroism. The complex is formed through slow recognition kinetics that is temperature sensitive in the range of 20°C-37°C. The overall reaction was observed to be endothermic (ΔH = 204 kJ mol(-1)) and entropy driven (ΔS = 746 J mol(-1)K(-1)) with overall small changes to the tertiary structure.
采用表面等离子体共振和圆二色性研究了环脂肽A与人血清白蛋白结合的动力学、能量学和结构。该复合物通过缓慢的识别动力学形成，该动力学在20°C至37°C范围内对温度敏感。观察到整个反应是吸热的（ΔH = 204 kJ mol(-1)）且由熵驱动（ΔS = 746 J mol(-1)K(-1)），三级结构总体变化较小。
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