Picur Bolesław, Cebrat Marek, Zabrocki Janusz, Siemion Ignacy Z
Faculty of Chemistry, University of Wroclaw, 14 F. Joliot-Curie, 50-383 Wroclaw, Poland.
J Pept Sci. 2006 Sep;12(9):569-74. doi: 10.1002/psc.779.
Cyclolinopeptide A (CLA), a cyclic nonapeptide from linseed, possesses strong immunosuppressive and antimalarial activity along with the ability to inhibit cholate uptake into hepatocytes. The structure of the peptide was studied extensively in solution as well as in the solid state. It is postulated that both the Pro-Pro cis-amide bond and an 'edge-to-face' interaction between the aromatic rings of two adjacent Phe residues are important for biological activity. Structure-activity relationship studies of many linear and cyclic analogues of CLA suggest that the Pro-Xxx-Phe sequence and the flexibility of the peptide are important for the immunosuppressive activity.
环亚麻肽A（CLA）是一种来自亚麻籽的环九肽，具有强大的免疫抑制和抗疟活性，同时还能抑制胆酸盐进入肝细胞。该肽的结构在溶液和固态中都得到了广泛研究。据推测，脯氨酸-脯氨酸顺式酰胺键以及两个相邻苯丙氨酸残基的芳香环之间的“边对面”相互作用对生物活性很重要。CLA许多线性和环状类似物的构效关系研究表明，脯氨酸-Xxx-苯丙氨酸序列和肽的灵活性对免疫抑制活性很重要。
