Department of Internal Medicine and Geriatrics, Angers University Hospital, Angers, France.
J Nutr Health Aging. 2011 Apr;15(4):271-6. doi: 10.1007/s12603-011-0037-1.
To determine whether there was an association between the Five-Times-Sit-to-Stand test (FTSS) and the global cognitive function assessed with Short-Portable-Mental-State-Questionnaire (SPMSQ) among the EPIDOS cohort.
Cross-sectional study corresponding to the baseline assessment of the EPIDOS study.
Five French cities including Amiens, Lyon, Montpellier, Paris and Toulouse.
7421 community-dwelling older women (mean age 80.41 ± 0.04 years).
Time to achieve FTSS, and SPMSQ score. Age, body mass index, high number of comorbidities, cardiovascular risk factors, depression, regular physical activity, joint pain, quadriceps strength, visual acuity, use of psychoactive drugs, serum albumin, vitamin D deficiency (i.e., serum concentration < 10 ng/mL), and the influence of seasons and study centers were used as covariables. Subjects were divided into 2 groups according to SPMSQ score (either impaired < 8/10 or normal ≥ 8/10).
Compared to their counterparts, the women with cognitive impairment (n=1190, mean 81.51 ± 0.45 years) took more time in performing FTSS (17.8± 0.9 seconds versus 16.1 ± 0.3 seconds, P < 0.001). There was a significant negative association of SPMSQ score with FTSS (Unadjusted β=-0.02(95%CI -0.03;-0.01), P< 0.001; Fully Adjusted β=-0.03(95%CI -0.05;-0.01), P=0.003; Stepwise Backward Adjusted β=-0.02(95%CI -0.04;-0.01), P=0.005), as well as with advance in age (β=-0.04, P=0.006) and vitamin D deficiency (β=-0.34, P=0.011). The FTSS limit value in predicting moderate cognitive impairment was set at 15 seconds by a sensitivity analysis (negative predictive value=86%).
We found a negative association of FTSS with global cognitive performance. Achieving FTSS in less than 15 seconds made unlikely the existence of a moderate cognitive impairment. FTSS could be used as a tool in primary care medicine to exclude moderate cognitive decline.
在 EPIDOS 队列中，确定五倍坐立测试（FTSS）与使用简易精神状态问卷（SPMSQ）评估的整体认知功能之间是否存在关联。
对应于 EPIDOS 研究的基线评估的横断面研究。
包括亚眠、里昂、蒙彼利埃、巴黎和图卢兹在内的法国五个城市。
7421 名居住在社区的老年女性（平均年龄 80.41±0.04 岁）。
FTSS 完成时间和 SPMSQ 评分。年龄、体重指数、多种合并症、心血管危险因素、抑郁、规律的身体活动、关节疼痛、股四头肌力量、视力、精神活性药物的使用、血清白蛋白、维生素 D 缺乏症（即血清浓度＜10ng/ml）以及季节和研究中心的影响均作为协变量。根据 SPMSQ 评分（受损＜8/10 或正常≥8/10）将受试者分为两组。
与对照组相比，认知障碍女性（n=1190，平均年龄 81.51±0.45 岁）完成 FTSS 的时间更长（17.8±0.9 秒比 16.1±0.3 秒，P＜0.001）。SPMSQ 评分与 FTSS 呈显著负相关（未调整β=-0.02（95%CI-0.03；-0.01），P＜0.001；完全调整β=-0.03（95%CI-0.05；-0.01），P=0.003；逐步向后调整β=-0.02（95%CI-0.04；-0.01），P=0.005），以及与年龄的增长（β=-0.04，P=0.006）和维生素 D 缺乏症（β=-0.34，P=0.011）有关。通过敏感性分析，将 FTSS 的预测值设定为 15 秒，以确定中度认知障碍（阴性预测值=86%）。
我们发现 FTSS 与整体认知表现呈负相关。在 15 秒内完成 FTSS 不太可能存在中度认知障碍。FTSS 可作为初级保健医学中的一种工具，用于排除中度认知能力下降。
