膳食维生素 D 摄入量与老年女性的肌肉量。EPIDOS 研究的横断面分析结果。

Dietary vitamin D intake and muscle mass in older women. Results from a cross-sectional analysis of the EPIDOS study.

机构信息

Gérontopôle, Department of Internal Medicine and Geriatrics, Toulouse University Hospital, Toulouse, France.

出版信息

J Nutr Health Aging. 2013 Feb;17(2):119-24. doi: 10.1007/s12603-012-0089-x.

DOI:10.1007/s12603-012-0089-x

PMID:23364488

Abstract

OBJECTIVES

Vitamin D intake may prevent physical performance decline through prevention of muscle mass loss. Our objective was to determine whether low dietary intakes were associated with low muscle mass (MM).

DESIGN AND PARTICIPANTS

Cross-sectional analysis of 1989 community-dwelling women (mean age 80.5±3.8years) from the EPIDémiologie de l'OStéoporose (EPIDOS) study were assessed at baseline.

MEASUREMENTS

Low intakes of vitamin D (<70µg/week) were estimated from the weekly dietary vitamin D intakes (self-administered food frequency questionnaire). Low MM was defined according to the appendicular skeletal muscle mass index assessed using Dual Energy X-ray Absorptiometry, divided by square height of less than 5.45 kg/m2. Usual gait speed defined physical performance. Age, sun exposure, co-morbidities, education level, living arrangements, recreational physical activity, dietary protein and calcium intakes, bone mineral density, handgrip strength, and body mass index were considered as potential confounders. Multivariate logistic regression analyses assessed the association between low vitamin D intakes and low MM.

RESULTS

Two-hundred and nine (10.5%) women with low MM were compared to 1,780 women with normal MM. In final model, obesity/overweight (Adjusted Odds Ratios, aOR=0.09; 95%CI [0.05-0.17]), malnutrition (aOR=3.90; 95%CI [2.74-5.54]) and low handgrip strength (aOR=2.33; 95%CI [1.44-3.77]; p<0.001) were statistically associated with a low MM status.

CONCLUSION

No association with low MM has been reported regarding low dietary intakes of vitamin D.

摘要

目的

维生素 D 的摄入可能通过防止肌肉质量的损失来预防身体机能的下降。我们的目的是确定低饮食摄入量是否与低肌肉质量（MM）有关。

设计和参与者

横断面分析了来自 EPIDémiologie de l'OStéoporose（EPIDOS）研究的 1989 名社区居住的女性（平均年龄 80.5±3.8 岁），她们在基线时接受了评估。

测量

每周饮食维生素 D 摄入量（自我管理的食物频率问卷）估计了维生素 D 的低摄入量（<70μg/周）。低 MM 根据使用双能 X 射线吸收法评估的四肢骨骼肌质量指数定义，除以身高的平方小于 5.45kg/m2。常用的步速定义了身体机能。年龄、阳光暴露、合并症、教育水平、居住安排、娱乐性体力活动、饮食蛋白质和钙摄入量、骨矿物质密度、握力和体重指数被认为是潜在的混杂因素。多变量逻辑回归分析评估了低维生素 D 摄入量与低 MM 之间的关联。

结果

209 名（10.5%）低 MM 女性与 1780 名正常 MM 女性进行了比较。在最终模型中，肥胖/超重（调整后的优势比，aOR=0.09；95%CI [0.05-0.17]）、营养不良（aOR=3.90；95%CI [2.74-5.54]）和低握力（aOR=2.33；95%CI [1.44-3.77]；p<0.001）与低 MM 状态有统计学关联。