维生素 D 膳食摄入量与老年女性认知功能的关系：一项基于大样本的研究。

Dietary intake of vitamin D and cognition in older women: a large population-based study.

机构信息

Department of Internal Medicine and Geriatrics, Angers University Hospital, Angers University Memory Center, UPRES EA 2646, University of Angers, UNAM, Angers, France.

出版信息

Neurology. 2010 Nov 16;75(20):1810-6. doi: 10.1212/WNL.0b013e3181fd6352.

DOI:10.1212/WNL.0b013e3181fd6352

PMID:21079183

Abstract

BACKGROUND

Serum vitamin D concentrations are associated with global cognitive function among older adults. The benefits of vitamin D intake to treat or prevent cognitive impairment remain unknown. The objective of this cross-sectional study was to determine whether weekly dietary intake of vitamin D could be associated with global cognitive performance among older adults.

METHODS

A total of 5,596 community-dwelling women (mean age 80.5 ± 0.1 years) free of vitamin D drug supplements from the Epidémiologie de l'Ostéoporose (EPIDOS) study were divided into 2 groups according to baseline weekly vitamin D dietary intake (either inadequate <35 μg/wk or recommended ≥35μg/wk). Weekly vitamin D dietary intakes were estimated from a self-administered food frequency questionnaire. Cognitive impairment was defined as a Pfeiffer Short Portable Mental State Questionnaire (SPMSQ) score <8. Age, body mass index, sun exposure at midday, season, disability, number of chronic diseases, hypertension, depression, use of psychoactive drugs, and education level were considered as potential confounders.

RESULTS

Compared to women with recommended weekly vitamin D dietary intakes (n = 4,802; mean age 80.4 ± 3.8 years), women with inadequate intakes (n = 794; mean age 81.0 ± 3.8 years) had a lower mean SPMSQ score (p < 0.001) and more often had an SPMSQ score <8 (p = 0.002). We found an association between weekly vitamin D dietary intake and SPMSQ score (β = 0.002, p < 0.001). Inadequate weekly vitamin D dietary intakes were also associated with cognitive impairment (unadjusted odds ratio = 1.42 with p = 0.002; full adjusted odds ratio = 1.30 with p = 0.024).

CONCLUSIONS

Weekly dietary intake of vitamin D was associated with cognitive performance in older women.

摘要

背景

血清维生素 D 浓度与老年人的整体认知功能有关。维生素 D 摄入对治疗或预防认知障碍的益处尚不清楚。本横断面研究的目的是确定老年人每周的饮食维生素 D 摄入量是否与整体认知表现相关。

方法

共有 5596 名居住在社区的女性（平均年龄 80.5±0.1 岁）参加了 Epidémiologie de l'Ostéoporose（EPIDOS）研究，且均未服用维生素 D 药物补充剂，她们根据基线时每周的维生素 D 饮食摄入量（不足<35μg/周或建议≥35μg/周）分为 2 组。每周的维生素 D 饮食摄入量是根据自我管理的食物频率问卷来估计的。认知障碍定义为 Pfeiffer 短期便携式精神状态问卷（SPMSQ）评分<8。年龄、体重指数、中午的阳光照射、季节、残疾、慢性疾病数量、高血压、抑郁、使用精神药物和教育程度被认为是潜在的混杂因素。

结果

与每周推荐的维生素 D 饮食摄入量（n=4802；平均年龄 80.4±3.8 岁）的女性相比，每周摄入量不足（n=794；平均年龄 81.0±3.8 岁）的女性 SPMSQ 评分更低（p<0.001），且 SPMSQ 评分<8 的情况更常见（p=0.002）。我们发现每周的维生素 D 饮食摄入量与 SPMSQ 评分之间存在关联（β=0.002，p<0.001）。每周维生素 D 饮食摄入量不足也与认知障碍有关（未调整的优势比=1.42，p=0.002；完全调整的优势比=1.30，p=0.024）。