HIV 感染成人认知功能和药物治疗依从性的纵向变化。
Longitudinal change in cognitive function and medication adherence in HIV-infected adults.
机构信息
Neuropsychology Lab, VA Greater Los Angeles Health Care System, CA 90073, USA.
出版信息
AIDS Behav. 2011 Nov;15(8):1888-94. doi: 10.1007/s10461-011-9924-z.
Abstract
Neuropsychological (NP) dysfunction has been linked to poor medication adherence among HIV-infected adults. However, there is a dearth of research examining longitudinal changes in the relationship between NP status and adherence rates. We hypothesized that declines in NP functioning would be associated with a corresponding decline in medication adherence while stable NP functioning would be associated with stable or improving adherence rates. Participants included 215 HIV-infected adults who underwent cognitive testing at study entry and six months later. Compared to the NP stable group, the NP decline group showed a greater drop in adherence rates. Further analysis revealed that, beyond global NP, learning and memory was significantly associated with changes in adherence rates. These findings further support the link between cognitive functioning and medication adherence and illustrates the importance of documenting changes in cognitive abilities for identifying individuals at risk for poor adherence.
摘要
神经心理学（NP）功能障碍与 HIV 感染成年人药物依从性差有关。然而，目前缺乏研究来检验 NP 状态与药物依从率之间关系的纵向变化。我们假设，NP 功能的下降与药物依从率的相应下降有关，而 NP 功能的稳定则与稳定或改善的药物依从率有关。参与者包括 215 名在研究开始时和六个月后接受认知测试的 HIV 感染成年人。与 NP 稳定组相比，NP 下降组的药物依从率下降幅度更大。进一步的分析表明，除了整体 NP 之外，学习和记忆能力与药物依从率的变化显著相关。这些发现进一步支持认知功能与药物依从性之间的联系，并说明了记录认知能力变化以识别药物依从性差风险个体的重要性。
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