Crinnion Walter J
Environmental Medicine Program, Southwest College of Naturopathic Medicine, Tempe, AZ, USA.
Altern Med Rev. 2011 Mar;16(1):5-13.
Polychlorinated biphenyls (PCBs) are considered "persistent organic pollutants;" fat-soluble compounds that bioaccumulate in individuals and bio-magnify in the food chain. PCBs were the first industrial compounds to experience a worldwide ban on production because of their potent toxicity. These compounds are still present in our food supply (fish, dairy, hamburger, and poultry being the most contaminated) and our bodies. Once in the body, they can cause long-term problems, especially for those exposed in utero. PCB bioaccumulation can lead to reduced infection fighting ability, increased rates of autoimmunity, cognitive and behavioral problems, and hypothyroidism. Some research also links PCBs to increased rates of type 2 diabetes. Testing is currently available for some of the most damaging PCBs. The testing compares individual levels to national reference values and can be interpreted to determine current exposure. Dietary measures can be enacted that will reduce PCB half-lives in humans by increasing excretion.
多氯联苯（PCBs）被视为“持久性有机污染物”；它们是脂溶性化合物，会在个体体内生物累积，并在食物链中生物放大。由于其强大的毒性，多氯联苯是首批在全球范围内被禁止生产的工业化合物。这些化合物仍存在于我们的食物供应中（鱼类、乳制品、汉堡和家禽受污染最为严重）以及我们的体内。一旦进入人体，它们会引发长期问题，尤其是对那些在子宫内就接触到多氯联苯的人。多氯联苯的生物累积会导致抗感染能力下降、自身免疫率上升、认知和行为问题以及甲状腺功能减退。一些研究还将多氯联苯与2型糖尿病发病率的上升联系起来。目前可以对一些最具危害性的多氯联苯进行检测。该检测将个体水平与国家参考值进行比较，并可据此解读以确定当前的接触情况。可以采取饮食措施，通过增加排泄来缩短多氯联苯在人体内的半衰期。
