Department of Pediatrics, University of Colorado, 12801 E 17th Ave, RC-1 South, Rm 6400D, Mail Stop 8303, Aurora, CO 80045, USA.
Pharmacol Ther. 2011 Jul;131(1):130-41. doi: 10.1016/j.pharmthera.2011.03.009. Epub 2011 Mar 23.
Autophagy is a catabolic process that turns over long-lived proteins and organelles and contributes to cell and organism survival in times of stress. Current cancer therapies including chemotherapy and radiation are known to induce autophagy within tumor cells. This is therefore an attractive process to target during cancer therapy as there are safe, clinically available drugs known to both inhibit and stimulate autophagy. However, there are conflicting positive and negative effects of autophagy and no current consensus on how to manipulate autophagy to improve clinical outcomes. Careful and rigorous evaluation of autophagy with a focus on how to translate laboratory findings into relevant clinical therapies remains an important aspect of improving clinical outcomes in patients with malignant disease.
自噬是一种分解代谢过程，可分解长寿命的蛋白质和细胞器，并有助于细胞和生物体在应激时存活。目前已知包括化疗和放疗在内的癌症疗法可诱导肿瘤细胞内的自噬。因此，在癌症治疗期间靶向该过程是一种有吸引力的方法，因为有已知安全且可临床应用的药物可同时抑制和刺激自噬。然而，自噬的作用既有积极的也有消极的，目前尚无共识如何操纵自噬以改善临床结果。仔细和严格地评估自噬，并专注于如何将实验室发现转化为相关的临床治疗方法，仍然是改善恶性疾病患者临床结果的一个重要方面。
