儿童应用 HeartWare 心室辅助系统的初步经验。

First experiences with the HeartWare ventricular assist system in children.

机构信息

Department of Pediatric Cardiology, Deutsches Herzzentrum Berlin, Germany.

出版信息

Ann Thorac Surg. 2011 Apr;91(4):1256-60. doi: 10.1016/j.athoracsur.2010.12.013.

DOI:10.1016/j.athoracsur.2010.12.013

PMID:21440155

Abstract

PURPOSE

The purpose of this study is to describe initial experience with a new continuous flow, ventricular assist system in the pediatric population.

DESCRIPTION

Seven children (aged 6 to 16 years) received implantation of a novel third-generation, continuous flow, ventricular assist device (HeartWare, HeartWare Inc, Miami Lakes, FL) as a bridge to cardiac transplantation.

EVALUATION

All children were in terminal heart failure despite inotropic support, and signs of renal or hepatic impairment developed. Six children had dilatative cardiomyopathy and 1 had congenital heart disease (hypoplastic left heart, total cavopulmonary connections with extracardiac conduit). Six patients have been successfully bridged to transplantation. Median support time was 75 days (range, 1 to 136 days). One child is still under continuous mechanical support. None of the patients suffered a thromboembolic event or an infection.

CONCLUSIONS

The HeartWare assist system can be successfully used as a bridge to transplantation in children and adolescents with end-stage heart failure.

摘要

目的

本研究旨在描述新型连续血流心室辅助系统在儿科人群中的初步经验。

描述

7 名儿童（年龄 6 至 16 岁）接受了新型第三代连续流动心室辅助装置（HeartWare，HeartWare Inc，迈阿密湖，FL）的植入，作为心脏移植的桥接。

评估

所有儿童均存在终末期心力衰竭，尽管给予了正性肌力支持，但仍出现了肾功能或肝功能损害的迹象。6 名儿童患有扩张型心肌病，1 名患有先天性心脏病（左心发育不全，全腔静脉肺动脉连接伴心外导管）。6 名患者成功桥接移植。中位支持时间为 75 天（范围 1 至 136 天）。1 名儿童仍在持续机械支持下。没有患者发生血栓栓塞事件或感染。