Mullooly V M, Abramson A L, Shikowitz M J
Department of Otolaryngology and Communicative Disorders, Long Island Jewish Medical Center, New Hyde Park, New York 11042.
Lasers Surg Med. 1990;10(4):349-56. doi: 10.1002/lsm.1900100408.
Twenty-six patients with recurrent laryngeal papillomatosis received 2.5 mg/kg of Dihematoporphyrin Ether (DHE) intravenously prior to photodynamic therapy. All patients experienced some degree of photosensitivity, the only known side effect of DHE. Reported reactions included mild erythema and inflammation (88%), swelling (58%), blistering (23%), ocular discomfort (61.5%), pruritus (38%), and skin hyperpigmentation (46%). Length of sensitivity ranged from 4-17 weeks, with an average duration of 9 weeks. No long-term debilitating sequelae were noted. Degree of skin reaction mainly depended on how compliant the patient was in following precaution instructions. Although restrictive precautions were often difficult to strictly adhere to, most patients felt the potential benefits of the therapy far outweighed any inconvenience.
26例复发性喉乳头状瘤患者在光动力治疗前静脉注射2.5mg/kg的二血卟啉醚（DHE）。所有患者均出现了一定程度的光敏反应，这是DHE唯一已知的副作用。报告的反应包括轻度红斑和炎症（88%）、肿胀（58%）、水疱形成（23%）、眼部不适（61.5%）、瘙痒（38%）和皮肤色素沉着（46%）。敏感持续时间为4至17周，平均持续时间为9周。未发现长期致残性后遗症。皮肤反应的程度主要取决于患者遵守预防措施指示的情况。尽管严格的预防措施往往难以严格遵守，但大多数患者认为该治疗的潜在益处远远超过任何不便之处。
