Laboratory of Experimental Immunology, University Hospitals Leuven, Catholic University of Leuven , Leuven, Belgium.
Rhinology. 2010 Dec;48(4):426-32. doi: 10.4193/Rhino10.049.
Chronic rhinosinusitis with nasal polyposis (NP) represents an invalidating disorder that causes mainly nasal blockage and loss of smell. The aim of this study is to investigate correlations between individual subjective and objective parameters of stable NP disease.
65 NP patients scored their sinonasal symptoms on a visual analogue scale (VAS) and questionnaires (SNOT-22 and SF-36). Peak nasal inspiratory flow (PNIF) measurement, Sniffinatm Sticks (SS) smell test, blood analysis for eosinophilia, total IgE and culture for Staphylococcus aureus (SA) were performed.
VAS scores for nasal blockage correlated with the SNOT-22 and SF-36 scores, which was not observed for VAS of other symptoms. VAS scores for nasal blockage correlated well with PNIF values as well as VAS scores for smell dysfunction and SS results (both p<0.001). NP size correlated with VAS scores for nasal blockage (p<0.01) but not with VAS for other symptoms. NP size showed an inverse correlation with PNIF and SS scores (both p<0.05). Blood eosinophilia correlated with subjective smell reduction (p<0.05). The presence of SA or total IgE levels were not associated with symptoms of NP disease.
PNIF and SS are good tools to evaluate symptoms of nasal obstruction and smell reduction in NP disease. Nasal blockage is the only symptom that correlates well with NP size and SNOT-22 scores, whereas smell reduction correlates with blood eosinophilia.
伴有鼻息肉（NP）的慢性鼻-鼻窦炎是一种使人丧失能力的疾病，主要导致鼻塞和嗅觉丧失。本研究旨在探讨稳定型 NP 疾病患者个体主观和客观参数之间的相关性。
65 例 NP 患者使用视觉模拟评分（VAS）和问卷（SNOT-22 和 SF-36）对其鼻-鼻窦症状进行评分。进行峰值鼻吸气流量（PNIF）测量、Sniffinatm 棒（SS）嗅觉测试、嗜酸性粒细胞、总 IgE 血液分析和金黄色葡萄球菌（SA）培养。
鼻塞的 VAS 评分与 SNOT-22 和 SF-36 评分相关，但其他症状的 VAS 评分则不然。鼻塞的 VAS 评分与 PNIF 值以及嗅觉障碍的 VAS 评分和 SS 结果高度相关（均 p<0.001）。NP 大小与鼻塞的 VAS 评分相关（p<0.01），但与其他症状的 VAS 评分无关。NP 大小与 PNIF 和 SS 评分呈负相关（均 p<0.05）。血嗜酸性粒细胞计数与主观嗅觉减退相关（p<0.05）。SA 或总 IgE 水平与 NP 疾病的症状无关。
PNIF 和 SS 是评估 NP 疾病中鼻塞和嗅觉减退症状的良好工具。鼻塞是唯一与 NP 大小和 SNOT-22 评分高度相关的症状，而嗅觉减退与血嗜酸性粒细胞计数相关。
