[血浆同型半胱氨酸、叶酸及维生素B12在溃疡性结肠炎中的意义]
[Significance of plasmic homocysteine, folate and Vitamin B(12) in ulcerative colitis].
作者信息
Chen Mo-Li, Mei Qiao, Xu Jian-Ming, Hu Nai-Zhong, Lu Chun-Xia, Fang Hai-Ming
机构信息
Department of Gastroenterology, The Frist Affiliated Hospital, Anhui Medical University, The Key Laboratory of Digestive Diseases of Anhui Province, Hefei 230022, China.
出版信息
Zhonghua Wei Chang Wai Ke Za Zhi. 2011 Mar;14(3):185-7.
OBJECTIVE
To investigate the clinical significance of plasmic homocysteine (Hcy), folate (FA) and Vitamin B(12) (VitB(12)) in patients with ulcerative colitis (UC).
METHODS
Plasmic Hcy in 112 cases of UC patients and 110 controls were detected by HPLC-FD method. Plasmic FA, VitB(12) in 76 cases of UC patients and 12 controls were detected by enzyme-linked immunosorbent assay (ELISA) method.
RESULTS
The level of plasmic Hcy in UC patients was(11.27±7.26) μmol/L, significantly higher than that in controls[(8.19±4.81) μmol/L, P<0.05], and was not significantly correlated with disease index, extent and duration of UC(P>0.05). The level of FA and VitB(12) in UC patients were (7.64±1.95) nmol/L and (108.64±32.22) pmol/L respectively, lower than those in controls[(9.14±1.23) nmol/L and (112.64±33.33) pmol/L, P<0.05]. The level of plasmic Hcy was negatively correlated with the level of FA and VitB(12) in UC patients(P<0.05). The level of plasmic FA decreased to some extent with UC disease duration.
CONCLUSION
Plasmic Hcy is elevated in UC patients, which may be related to the decrease of FA and VitB(12).
目的
探讨血浆同型半胱氨酸（Hcy）、叶酸（FA）及维生素B12（VitB12）在溃疡性结肠炎（UC）患者中的临床意义。
方法
采用高效液相色谱-荧光检测法（HPLC-FD）检测112例UC患者及110例对照者的血浆Hcy水平。采用酶联免疫吸附测定法（ELISA）检测76例UC患者及12例对照者的血浆FA、VitB12水平。
结果
UC患者血浆Hcy水平为（11.27±7.26）μmol/L，显著高于对照组[（8.19±4.81）μmol/L，P<0.05]，且与UC的病情指数、病变范围及病程无显著相关性（P>0.05）。UC患者血浆FA、VitB12水平分别为（7.64±1.95）nmol/L和（108.64±32.
22）pmol/L，低于对照组[（9.14±1.23）nmol/L和（112.64±33.33）pmol/L，P<0.05]。UC患者血浆Hcy水平与FA、VitB12水平呈负相关（P<0.05）。随着UC病程延长，血浆FA水平有一定程度下降。
结论
UC患者血浆Hcy升高，可能与FA及VitB12降低有关。
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