Pitkänen Oli M, Helve Otto, Andersson Sture
Suomen Akatemian kliininen tutkija.
Duodecim. 2011;127(1):43-8.
When the lungs are flooding, pumps are needed - epithelial Na-channel in respiratory insuffiency For a newborn in order to adapt to breathing air, the lungs must gain a sufficient size and respiratory surface area, and the pulmonary circulation and interstitial lymph circulation must be functional. Any disturbance in these events will result in a chronic pulmonary disease. Transportation of sodium ions from the alveolar side of the mucous membrane into the interstitial and blood space has turned out to be an important factor in the airway surface liquid volume regulation. Deficiency of transepithelial fluid transport is a cause and eventual target for therapy of respiratory insufficiency appearing during the neonatal period or later.
当肺部出现积水时，就需要水泵——呼吸功能不全时的上皮钠通道 对于新生儿来说，为了适应呼吸空气，肺部必须获得足够的大小和呼吸表面积，并且肺循环和间质淋巴循环必须正常运作。这些过程中的任何干扰都将导致慢性肺部疾病。事实证明，钠离子从肺泡侧黏膜转运至间质和血液空间是气道表面液体量调节的一个重要因素。跨上皮液体转运不足是新生儿期或之后出现的呼吸功能不全的病因及最终治疗靶点。
