[镜像力在钾离子通道水孔中对通道通透性的作用——非局域静电效应]
[Role of image force in a water pore of K+ channel in the channel permeability--nonlocal electrostatic effects].
作者信息
Rubashkin A A, Iserovich P
出版信息
Biofizika. 2011 Jan-Feb;56(1):140-2.
A modified Parsegian formula for the calculation of the mage force in a water pore, which takes into account nonlocal electrostatic effects, has been applied to the analysis of changes in the permeability of K+ channels. It has been shown that the channel permeability increases 3 x 10(3) times as the width of the pore increases from 4 to 10 angstroms when the energy is calculated by the modified Parsegian formula and only 16 times if the classical Parsegian formula is used. We conclude that the image force in a water pore within K+ channels plays an important part in the change of channel permeability. Accounting for nonlocal electrostatic effects indicates that the permeability of the K+ channel is more strongly related to the size of the water pore than previously assumed by the original Parsegian formula.
一种用于计算水孔中镜像力的修正帕尔塞吉安公式，该公式考虑了非局部静电效应，已被应用于分析钾离子通道通透性的变化。结果表明，当通过修正帕尔塞吉安公式计算能量时，随着孔径从4埃增加到10埃，通道通透性增加3×10³倍；而如果使用经典帕尔塞吉安公式，通透性仅增加16倍。我们得出结论，钾离子通道内水孔中的镜像力在通道通透性变化中起重要作用。考虑非局部静电效应表明，钾离子通道的通透性与水孔大小的关系比原始帕尔塞吉安公式先前假设的更为密切。
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