Boesby S
Scand J Gastroenterol. 1977;12(5):547-51. doi: 10.3109/00365527709181333.
Twelve-hour continuous pH-recording at the distal end of the oesophagus and measurement of basal gastro-oesophageal sphincter pressure with perfused catheters were carried out in 108 subjects. Fasting gastric secretion, basal secretion, and maximal acid secretion after subcutaneous injection of 6 microgram pentagastrin/kg bodyweight were determined additionally in some of the subjects. There was a significant inverse correlation between the results of continuous pH-recording and basal gastro-oesophageal sphincter pressure, which confirms the relationship between low sphincter pressure and gastro-oesophageal acid reflux. Furthermore, there was a significant direct correlation between the results of continuous pH-recording and the volume of basal secretion and the basal acid output. These findings emphasize the significance of gastric acid secretion for the results of continuous pH-recording. As reflux-preventive surgery may elicit alterations in the variables of acid secretion, the results of continuous pH-recording do not allow conclusions to be drawn with regard to the effectiveness of a surgically established gastro-oesophageal barrier.
对108名受试者进行了食管远端12小时连续pH记录，并使用灌注导管测量了基础胃食管括约肌压力。另外，对部分受试者测定了空腹胃液分泌、基础分泌以及皮下注射6微克五肽胃泌素/千克体重后的最大胃酸分泌。连续pH记录结果与基础胃食管括约肌压力之间存在显著的负相关，这证实了括约肌压力降低与胃食管酸反流之间的关系。此外，连续pH记录结果与基础分泌量和基础酸排出量之间存在显著的正相关。这些发现强调了胃酸分泌对连续pH记录结果的重要性。由于抗反流手术可能会引起酸分泌变量的改变，因此连续pH记录结果无法就手术建立的胃食管屏障的有效性得出结论。
